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FLASH GENE

Symbol

APOO

contributors: mct - updated : 22-11-2017

HGNC name	apolipoprotein O
HGNC id	28727

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   overexpression of APOO induced fragmentation of mitochondria, promoted ROS formation and resulted in impaired mitochondrial respiration constitutional     --low   depletion led to alterations in mitochondrial ultrastructure and caused a significant reduction in the number of crista junctions

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	may be regarded as an independent inflammatory predictor of acute coronary syndrome (ACS) patients
Therapy target
	System Type Disorder Pubmed cardiovascular cardiomyopathy   targeting APOO-dependent metabolic remodeling has potential as a strategy to adjust heart metabolism and protect the myocardium from impaired contractility

ANIMAL & CELL MODELS