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FLASH GENE
Symbol APOO contributors: mct - updated : 22-11-2017
HGNC name apolipoprotein O
HGNC id 28727
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 - 1134 22 198 - 2015 25764979
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   highly Homo sapiens
Lymphoid/Immunetonsils   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • apolipoprotein O family
  • CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    text
  • three distinct forms: (1) a glycosylated and secreted 55kDa protein, (2) an ER/Golgi-resident form thereof, and (3) a non-glycosylated 22kDa mitochondrial protein
  • basic FUNCTION
  • apolipoprotein that is present predominantly in high density lipoprotein (HDL)
  • represents a link between impaired mitochondrial function and cardiomyopathy onset
  • APOO and APOOL, regulate their levels in an antagonistic manner
  • in liver enhances likely hepatic lipid accumulation by impairing mitochondrial function
  • is linked to cardiolipin metabolism and promotes crista junction formation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • CHCHD6, APOOL and APOO appear to be periphery subunits of the MICOS complex, because their depletion does not affect cristae morphology or stability of other components
  • APOO and APOOL were suggested to represent constituents of the mammalian Mitofilin/MINOS complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    overexpression of APOO induced fragmentation of mitochondria, promoted ROS formation and resulted in impaired mitochondrial respiration
    constitutional     --low  
    depletion led to alterations in mitochondrial ultrastructure and caused a significant reduction in the number of crista junctions
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • may be regarded as an independent inflammatory predictor of acute coronary syndrome (ACS) patients
  • Therapy target
    SystemTypeDisorderPubmed
    cardiovascularcardiomyopathy 
    targeting APOO-dependent metabolic remodeling has potential as a strategy to adjust heart metabolism and protect the myocardium from impaired contractility
    ANIMAL & CELL MODELS