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	HGNC	UniGene	Nucleotide	OMIM		UCSC

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FLASH GENE

Symbol

STIL

contributors: mct - updated : 23-08-2014

HGNC name	SCL/TAL1 interrupting locus
HGNC id	10879

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

MCPH7

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral fusion       fused with TAL1 in T cell acute lymphocytic leukemia tumoral     --over   in multiple cancers that correlated with the expression of mitotic spindle checkpoint genes and with increased metastatic potential

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer     suitable target for novel anticancer therapy

ANIMAL & CELL MODELS

	sil-/-mice lack lefty 1 expression and have a bilateral expression of left-side specific genes
	dominant mutation, night blindness b (nbb), causes a late onset of retinal dopaminergic cell degeneration in zebrafish