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FLASH GENE
Symbol STIL contributors: mct - updated : 23-08-2014
HGNC name SCL/TAL1 interrupting locus
HGNC id 10879
ASSOCIATED DISORDERS
corresponding disease(s) MCPH7
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral fusion      
fused with TAL1 in T cell acute lymphocytic leukemia
tumoral     --over  
in multiple cancers that correlated with the expression of mitotic spindle checkpoint genes and with increased metastatic potential
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
cancer  
suitable target for novel anticancer therapy
ANIMAL & CELL MODELS
  • sil-/-mice lack lefty 1 expression and have a bilateral expression of left-side specific genes
  • dominant mutation, night blindness b (nbb), causes a late onset of retinal dopaminergic cell degeneration in zebrafish