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FLASH GENE
Symbol DLX1 contributors: mct/npt - updated : 10-01-2024
HGNC name distal-less homeo box 1
HGNC id 2914
DNA
TYPE functioning gene
STRUCTURE 4.17 kb     3 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 2356 27.2 255 - 2003 14671321
2 - 2156 13.4 129 - 2003 14671321
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text forebrain, facial and limb primordia
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • helix-turn-helix, DNA binding domain
    • HOMOLOGY
    interspecies homolog to Drosophila distal less Dlx1
    Homologene
    FAMILY
  • distal-less homeobox family
    • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • likely playing a regulatory role in the development of the ventral forebrain
  • RGS5 and DLX1 represent novel molecular targets for the regulation of ductus arteriosus (DA) maturation and closure
  • DLX1/DLX2 homeobox genes regulate GABA synthesis during forebrain development through direct activation of glutamic acid decarboxylase enzyme isoforms that convert glutamate to GABA
  • DLX1 and DLX2 promote interneuron GABA synthesis, synaptogenesis, and dendritogenesis
  • DLX1 exerted the oncogenic roles on the prostate cancer by activating beta-catenin/TCF signaling
    • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • OLIG1 is an essential repressor of DLX1/DLX2 and interneuron production in developing mammalian brain
  • DLX1 recruitment of SP7 to osteoblast enhancers underlies SP7-directed osteoblast specification
  • DLX1 is identified as a potential downstream gene of SATB2 in regulating the development of arcuate nucleus (ARC) neurons
  • DLX1 and DLX2 were reduced after SMG6 deletion
    • cell & other
    REGULATION
    activated by MSX1 (strongly up-regulated the Delta-Notch pathway genes DLK1, NOTCH3, and HEY1) (Revet 2008)
    ASSOCIATED DISORDERS
    corresponding disease(s) DEL2Q31
    Susceptibility to autism autism spectrum disorders
    Variant & Polymorphism SNP increasing the risk of autism spectrum disorders (Liu 2009)
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS