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FLASH GENE
Symbol HFM1 contributors: mct/npt - updated : 23-03-2021
HGNC name helicase for meiosis 1
HGNC id 20193
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • seven consecutive motifs conserved among the DEXH-box type of DNA/RNA helicases at the N-terminal
  • a single putative zinc finger motif at the C-terminal regions
    • HOMOLOGY
    interspecies homolog to yeast Mer3
    Homologene
    FAMILY
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    intracellular,nucleus
    text
  • in addition to its cytoplasmic distribution, HFM1 accumulated at the spindle poles, colocalized with the Golgi marker protein, GM130
    • basic FUNCTION
  • putative human DNA helicase, which may function as a modulator for genome integrity in germ-line tissues
  • is required to form normal numbers of crossovers (CO) and to complete synapsis
  • participates likely in Golgi-associated spindle assembly
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) POF9
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS