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FLASH GENE
Symbol HFM1 contributors: mct/npt - updated : 23-03-2021
HGNC name helicase for meiosis 1
HGNC id 20193
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivefemale systemuterus   
 female systemovary  highly
 male systemtestis   
Respiratoryrespiratory tractlarynx  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cells
SystemCellPubmedSpeciesStageRna symbol
Reproductivegerm cell Homo sapiens
cell lineage
cell lines
fluid/secretion blood
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • seven consecutive motifs conserved among the DEXH-box type of DNA/RNA helicases at the N-terminal
  • a single putative zinc finger motif at the C-terminal regions
  • HOMOLOGY
    interspecies homolog to yeast Mer3
    Homologene
    FAMILY
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    intracellular,nucleus
    text
  • in addition to its cytoplasmic distribution, HFM1 accumulated at the spindle poles, colocalized with the Golgi marker protein, GM130
  • basic FUNCTION
  • putative human DNA helicase, which may function as a modulator for genome integrity in germ-line tissues
  • is required to form normal numbers of crossovers (CO) and to complete synapsis
  • participates likely in Golgi-associated spindle assembly
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) POF9
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS