Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

HFM1

contributors: mct/npt - updated : 23-03-2021

HGNC name	helicase for meiosis 1
HGNC id	20193

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Reproductive female system uterus         female system ovary     highly   male system testis       Respiratory respiratory tract larynx     highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal

cells

System Cell Pubmed Species Stage Rna symbol Reproductive germ cell Homo sapiens

cell lineage
cell lines
fluid/secretion	blood

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	seven consecutive motifs conserved among the DEXH-box type of DNA/RNA helicases at the N-terminal
	a single putative zinc finger motif at the C-terminal regions

HOMOLOGY

interspecies

homolog to yeast Mer3

Homologene

FAMILY

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
	intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
	intracellular,nucleus
text	in addition to its cytoplasmic distribution, HFM1 accumulated at the spindle poles, colocalized with the Golgi marker protein, GM130

basic FUNCTION	putative human DNA helicase, which may function as a modulator for genome integrity in germ-line tissues
	is required to form normal numbers of crossovers (CO) and to complete synapsis
	participates likely in Golgi-associated spindle assembly

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

POF9

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS