Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Orphanet	Ensembl
	HGNC	UniGene	Nucleotide	OMIM		UCSC

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FLASH GENE

Symbol

KDR

contributors: mct - updated : 19-05-2017

HGNC name	kinase insert domain receptor (a type III receptor tyrosine kinase)
HGNC id	6307

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional somatic mutation       in juvenile hemangioma tumoral     --over   in invasive ovarian cancer tumoral   amplification     coamplification of PDGFRA or KDR with KIT may be clinically useful novel molecular markers in medulloblastomas and primitive neuroectodermal tumors constitutional     --low   in coronary artery disease where cardiac tissue has been subjected to prolonged or chronic hypoxia constitutional     --low   loss of expression of FLT1, moderate expression of KDR and high concentration of nitrate associated with aneurysm formation constitutional     --low   decreased expression of FLT1 in decidua and weaker VEGFA and KDR expression in placental villi and decidua may be associated with early pregnancy loss

Susceptibility

to coronary heart disease

Variant & Polymorphism SNP	SNP1192 and SNP1719 associated with risk of coronary heart disease

Candidate gene	early marker for endothelial cell progenitors
Marker
Therapy target
	System Type Disorder Pubmed tumor     blocking EFNB2 signaling in tumors might represent an intriguing strategy to interfere simultaneously with both KDR and FLT4 function that could be used as an alternative or combinatorial anti-angiogenic treatment for tumor therapy tumor     blocking ephrin-B2 reverse signaling may be an attractive alternative or combinatorial anti-angiogenic therapy strategy to disrupt KDR function in tumour angiogenesis tumor     inhibition of tyrosine phosphorylation of KDR by wogonin, correlated with a significant decrease in VEGF-triggered phosphorylated forms of ERK, AKT1 and MAPK14, associated with suppression of tumor growth

ANIMAL & CELL MODELS