Citations for
1KDR, MUC5AC, VEGFA
Upregulation of MUC5AC by VEGF in human primary bronchial epithelial cells: implications for asthma.
Kim SH, Pei QM, Jiang P, Liu J, Sun RF, Qian XJ, Liu JB.
Respir Res. Dec 12;20(1):282. doi: 10.1186/s12931-019-1245-1. 2019
2KDR, RABEP2
The Rab-effector protein RABEP2 regulates endosomal trafficking to mediate vascular endothelial growth factor receptor-2 (VEGFR2)-dependent signaling.
Kofler N, Corti F, Rivera-Molina F, Deng Y, Toomre D, Simons M.
J Biol Chem 293(13):4805-4817. doi: 10.1074/jbc.M117.812172. Epub 2018 Feb 7. 2018
3CLEC14A, FLT4, KDR
Carbohydrate-binding protein CLEC14A regulates VEGFR-2- and VEGFR-3-dependent signals during angiogenesis and lymphangiogenesis.
Lee S, Rho SS, Park H, Park JA, Kim J, Lee IK, Koh GY, Mochizuki N, Kim YM, Kwon YG.
J Clin Invest 127(2):457-471. doi: 10.1172/JCI85145. Epub 2016 Dec 19. 2017
4JAM3, KDR
JAM-C maintains VEGR2 expression to promote retinal pigment epithelium cell survival under oxidative stress.
Jia X, Zhao C, Chen Q, Du Y, Huang L, Ye Z, Ren X, Wang S, Lee C, Tang Z, Li X, Ju R.
Thromb Haemost. Apr 3;117(4):750-757. doi: 10.1160/TH16-11-0885. Epub 2017 Feb 16 2017
5GREM1, KDR
Gremlin regulates renal inflammation via the vascular endothelial growth factor receptor 2 pathway.
Lavoz C, Alique M, Rodrigues-Diez R, Pato J, Keri G, Mezzano S, Egido J, Ruiz-Ortega M.
J Pathol 236(4):407-20. doi: 10.1002/path.4537. Epub 2015 May 19. 2015
6KDR, TBX1
TBX1 Represses Vegfr2 Gene Expression and Enhances the Cardiac Fate of VEGFR2+ Cells.
Lania G, Ferrentino R, Baldini A.
PLoS One 10(9):e0138525. doi: 10.1371/journal.pone.0138525. eCollection 2015 Sep 18. 2015
7BSG, KDR
EMMPRIN/CD147 is a novel coreceptor of VEGFR-2 mediating its activation by VEGF.
Khayati F, Pérez-Cano L, Maouche K, Sadoux A, Boutalbi Z, Podgorniak MP, Maskos U, Setterblad N, Janin A, Calvo F, Lebbé C, Menashi S, Fernandez-Recio J, Mourah S.
Oncotarget 6(12):9766-80. 2015
8FLT1, KDR, VEGFA
The role of VEGF and its receptors in the etiology of early pregnancy loss.
Cöl-Madendag I, Madendag Y, Altinkaya SÖ, Bayramoglu H, Danisman N.
Gynecol Endocrinol 30(2):153-6. doi: 10.3109/09513590.2013.864272. Epub 2013 Dec 4. 2014
9KDR, MYO1C
The myosin motor Myo1c is required for VEGFR2 delivery to the cell surface and for angiogenic signaling.
Tiwari A, Jung JJ, Inamdar SM, Nihalani D, Choudhury A.
Am J Physiol Heart Circ Physiol 304(5):H687-96. doi: 10.1152/ajpheart.00744.2012. Epub 2012 Dec 21. 2013
10C1GALT1C1, KDR
COSMC is overexpressed in proliferating infantile hemangioma and enhances endothelial cell growth via VEGFR2.
Lee J Jr, Chen CH, Chen YH, Huang MJ, Huang J, Hung JS, Chen MT, Huang MC.
PLoS One 8(2):e56211. doi: 10.1371/journal.pone.0056211. Epub 2013 Feb 12. 2013
11KDR, UQCRB
Mitochondrial UQCRB regulates VEGFR2 signaling in endothelial cells.
Jung HJ, Kim Y, Chang J, Kang SW, Kim JH, Kwon HJ.
J Mol Med (Berl). Sep;91(9):1117-28. doi: 10.1007/s00109-013-1049-6. Epub 2013 May 25 2013
12KDR, MCAM
CD146 is a coreceptor for VEGFR-2 in tumor angiogenesis.
Jiang T, Zhuang J, Duan H, Luo Y, Zeng Q, Fan K, Yan H, Lu D, Ye Z, Hao J, Feng J, Yang D, Yan X.
Blood 120(11):2330-9. doi: 10.1182/blood-2012-01-406108. Epub 2012 Jun 20. 2012
13KDR, SH2D2A
VEGFR2 induces c-Src signaling and vascular permeability in vivo via the adaptor protein TSAd.
Sun Z, Li X, Massena S, Kutschera S, Padhan N, Gualandi L, Sundvold-Gjerstad V, Gustafsson K, Choy WW, Zang G, Quach M, Jansson L, Phillipson M, Abid MR, Spurkland A, Claesson-Welsh L.
J Exp Med 209(7):1363-77. doi: 10.1084/jem.20111343. Epub 2012 Jun 11. 2012
14DLL4, FLT4, KDR, NOTCH1
Notch-dependent VEGFR3 upregulation allows angiogenesis without VEGF-VEGFR2 signalling.
Benedito R, Rocha SF, Woeste M, Zamykal M, Radtke F, Casanovas O, Duarte A, Pytowski B, Adams RH.
Nature 484(7392):110-4. doi: 10.1038/nature10908. 2012
15FLT1, KDR, VEGFA
The role of heterodimerization between VEGFR-1 and VEGFR-2 in the regulation of endothelial cell homeostasis.
Cudmore MJ, Hewett PW, Ahmad S, Wang KQ, Cai M, Al-Ani B, Fujisawa T, Ma B, Sissaoui S, Ramma W, Miller MR, Newby DE, Gu Y, Barleon B, Weich H, Ahmed A.
Nat Commun 3:972. doi: 10.1038/ncomms1977. 2012
16FLT1, KDR
Elevated vascular endothelial growth factor receptor-2 abundance contributes to increased angiogenesis in vascular endothelial growth factor receptor-1-deficient mice.
Ho VC, Duan LJ, Cronin C, Liang BT, Fong GH.
Circulation 126(6):741-52. doi: 10.1161/CIRCULATIONAHA.112.091603. Epub 2012 Jun 29. 2012
17KDR, VEGFA
Endocardial cells form the coronary arteries by angiogenesis through myocardial-endocardial VEGF signaling.
Wu B, Zhang Z, Lui W, Chen X, Wang Y, Chamberlain AA, Moreno-Rodriguez RA, Markwald RR, O'Rourke BP, Sharp DJ, Zheng D, Lenz J, Baldwin HS, Chang CP, Zhou B.
Cell 151(5):1083-96. doi: 10.1016/j.cell.2012.10.023. 2012
18FLT1, KDR, VEGFA
Hypoxia differentially regulates VEGFR1 and VEGFR2 levels and alters intracellular signaling and cell migration in endothelial cells.
Ulyatt C, Walker J, Ponnambalam S.
Biochem Biophys Res Commun 404(3):774-9. Epub 2010 Dec 17. 2011
19KDR, NANOG
NANOG induction of fetal liver kinase-1 (FLK1) transcription regulates endothelial cell proliferation and angiogenesis.
Kohler EE, Cowan CE, Chatterjee I, Malik AB, Wary KK.
Blood 117(5):1761-9. Epub 2010 Nov 30. 2011
20KDR
PEST motif serine and tyrosine phosphorylation controls vascular endothelial growth factor receptor 2 stability and downregulation.
Meyer RD, Srinivasan S, Singh AJ, Mahoney JE, Gharahassanlou KR, Rahimi N.
Mol Cell Biol 31(10):2010-25. Epub 2011 Mar 14. 2011
21KDR, LGALS3
Galectin-3 protein modulates cell surface expression and activation of vascular endothelial growth factor receptor 2 in human endothelial cells.
Markowska AI, Jefferies KC, Panjwani N.
J Biol Chem 286(34):29913-21. Epub 2011 Jun 29. 2011
22KDR
The VEGFR2 receptor tyrosine kinase undergoes constitutive endosome-to-plasma membrane recycling.
Jopling HM, Howell GJ, Gamper N, Ponnambalam S.
Biochem Biophys Res Commun 410(2):170-6. Epub 2011 Apr 24. 2011
23HSPG2, KDR
Endorepellin, the angiostatic module of perlecan, interacts with both the α2β1 integrin and vascular endothelial growth factor receptor 2 (VEGFR2): a dual receptor antagonism.
Goyal A, Pal N, Concannon M, Paul M, Doran M, Poluzzi C, Sekiguchi K, Whitelock JM, Neill T, Iozzo RV.
J Biol Chem 286(29):25947-62. Epub 2011 May 19. 2011
24HSPB6, KDR
Acetylation of heat shock protein 20 (Hsp20) regulates human myometrial activity.
Karolczak-Bayatti M, Sweeney M, Cheng J, Edey L, Robson SC, Ulrich SM, Treumann A, Taggart MJ, Europe-Finner GN.
J Biol Chem 286(39):34346-55. Epub 2011 Jul 29. 2011
25KDR, OPRK1
The κ opioid system regulates endothelial cell differentiation and pathfinding in vascular development.
Yamamizu K, Furuta S, Katayama S, Narita M, Kuzumaki N, Imai S, Nagase H, Suzuki T, Narita M, Yamashita JK.
Blood 118(3):775-85. doi: 10.1182/blood-2010-09-306001. Epub 2011 Apr 1. 2011
26FLNA, FLNB, KDR, RAC1, VAV2
Filamin B plays a key role in vascular endothelial growth factor-induced endothelial cell motility through its interaction with Rac-1 and Vav-2.
Del Valle-Pérez B, Martínez VG, Lacasa-Salavert C, Figueras A, Shapiro SS, Takafuta T, Casanovas O, Capellà G, Ventura F, Viñals F.
J Biol Chem 285(14):10748-60. Epub 2010 Jan 28. 2010
27KDR, KIT, PDGFRA
Amplification and overexpression of KIT, PDGFRA, and VEGFR2 in medulloblastomas and primitive neuroectodermal tumors.
Blom T, Roselli A, Häyry V, Tynninen O, Wartiovaara K, Korja M, Nordfors K, Haapasalo H, Nupponen NN.
J Neurooncol 97(2):217-24. Epub 2009 Sep 25.PMID: 19779861 2010
28FLT4, KDR, TMEM204
Claudin-like protein 24 interacts with the VEGFR-2 and VEGFR-3 pathways and regulates lymphatic vessel development.
Saharinen P, Helotera H, Miettinen J, Norrmen C, D'Amico G, Jeltsch M, Langenberg T, Vandevelde W, Ny A, Dewerchin M, Carmeliet P, Alitalo K.
Genes Dev 24(9):875-80.PMID: 20439428 2010
29EFNB2, FLT4, KDR
Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis.
Wang Y, Nakayama M, Pitulescu ME, Schmidt TS, Bochenek ML, Sakakibara A, Adams S, Davy A, Deutsch U, Lüthi U, Barberis A, Benjamin LE, Mäkinen T, Nobes CD, Adams RH.
Nature 465(7297):483-6. 2010
30EFNB2, KDR
Ephrin-B2 regulates VEGFR2 function in developmental and tumour angiogenesis.
Sawamiphak S, Seidel S, Essmann CL, Wilkinson GA, Pitulescu ME, Acker T, Acker-Palmer A.
Nature 465(7297):487-91. Epub 2010 May 5. 2010
31KDR, KL, TRPC1
Klotho is associated with VEGF receptor-2 and the transient receptor potential canonical-1 Ca2+ channel to maintain endothelial integrity.
Kusaba T, Okigaki M, Matui A, Murakami M, Ishikawa K, Kimura T, Sonomura K, Adachi Y, Shibuya M, Shirayama T, Tanda S, Hatta T, Sasaki S, Mori Y, Matsubara H.
Proc Natl Acad Sci U S A 107(45):19308-13. Epub 2010 Oct 21. 2010
32KDR, MMP14, VEGFA
MT1-MMP regulates VEGF-A expression through a complex with VEGFR-2 and Src.
Eisenach PA, Roghi C, Fogarasi M, Murphy G, English WR.
J Cell Sci 123(Pt 23):4182-93. Epub 2010 Nov 9. 2010
33FLT1, KDR, VEGF1
Production of VEGF receptor 1 and 2 mRNA and protein during endochondral bone repair is differential and healing phase specific.
Reumann MK, Nair T, Strachna O, Boskey AL, Mayer-Kuckuk P.
J Appl Physiol 109(6):1930-8. Epub 2010 Oct 14. 2010
34FLT1, KDR
Expression of vascular endothelial growth factor receptor-1/-2 and nitric oxide in unruptured intracranial aneurysms.
Maderna E, Corsini E, Franzini A, Giombini S, Pollo B, Broggi G, Solero CL, Ferroli P, Messina G, Marras C.
Neurol Sci 31(5):617-23. Epub 2010 Jul 16. 2010
35FLT1, KDR
Soluble forms of VEGF receptor-1 and -2 promote vascular maturation via mural cell recruitment.
Lorquet S, Berndt S, Blacher S, Gengoux E, Peulen O, Maquoi E, Noël A, Foidart JM, Munaut C, Péqueux C.
FASEB J 24(10):3782-95. Epub 2010 May 19. 2010
36FLT1, KDR
VEGF-dependent tumor angiogenesis requires inverse and reciprocal regulation of VEGFR1 and VEGFR2.
Zhang Z, Neiva KG, Lingen MW, Ellis LM, Nör JE.
Cell Death Differ 17(3):499-512. Epub 2009 Oct 16. 2010
37CCL23, KDR
CCL23 up-regulates expression of KDR/Flk-1 and potentiates VEGF-induced proliferation and migration of human endothelial cells.
Han KY, Kim CW, Lee TH, Son Y, Kim J.
Biochem Biophys Res Commun 382(1):124-8. Epub 2009 Mar 3. Erratum in: Biochem Biophys Res Commun. 2009 Jun 19;384(1):131. 2009
38KDR, RAB5A, RAB7A
Rab GTPase regulation of VEGFR2 trafficking and signaling in endothelial cells.
Jopling HM, Odell AF, Hooper NM, Zachary IC, Walker JH, Ponnambalam S.
Arterioscler Thromb Vasc Biol 29(7):1119-24. Epub 2009 Apr 16. 2009
39KDR
Decursin inhibits VEGF-mediated inner blood-retinal barrier breakdown by suppression of VEGFR-2 activation.
Kim JH, Kim JH, Lee YM, Ahn EM, Kim KW, Yu YS.
J Cereb Blood Flow Metab 29(9):1559-67. Epub 2009 Jun 17. 2009
40KDR
Functional significance of VEGFR-2 on ovarian cancer cells.
Spannuth WA, Nick AM, Jennings NB, Armaiz-Pena GN, Mangala LS, Danes CG, Lin YG, Merritt WM, Thaker PH, Kamat AA, Han LY, Tonra JR, Coleman RL, Ellis LM, Sood AK.
Int J Cancer 124(5):1045-53.PMID: 19058181 2009
41FLT1, KDR, TEK, TIE1
Expression of VEGF receptors VEFGR-1 and VEGFR-2, angiopoietin receptors Tie-1 and Tie-2 in chorionic villi tree during early pregnancy.
Demir R.
Folia Histochem Cytobiol 47(3):435-45. 2009
42ANTXR1, FLT1, KDR
Suppressed NFAT-dependent VEGFR1 expression and constitutive VEGFR2 signaling in infantile hemangioma.
Jinnin M, Medici D, Park L, Limaye N, Liu Y, Boscolo E, Bischoff J, Vikkula M, Boye E, Olsen BR.
Nat Med 14(11):1236-46. Epub 2008 Oct 19. 2008
43KDR, PDGFA, VEGFA
2: A role for VEGF as a negative regulator of pericyte function and vessel maturation.
Greenberg JI, Shields DJ, Barillas SG, Acevedo LM, Murphy E, Huang J, Scheppke L, Stockmann C, Johnson RS, Angle N, Cheresh DA.
Nature 456(7223):809-13. Epub 2008 Nov 9. Erratum in: Nature. 2009 Feb 26;457(7233):1168. 2008
44KDR, WNT2
Wnt2 acts as a cell type-specific, autocrine growth factor in rat hepatic sinusoidal endothelial cells cross-stimulating the VEGF pathway.
Klein D, Demory A, Peyre F, Kroll J, Augustin HG, Helfrich W, Kzhyshkowska J, Schledzewski K, Arnold B, Goerdt S.
Hepatology 47(3):1018-31.PMID: 18302287 2008
45KDR
Wogonin suppresses tumor growth in vivo and VEGF-induced angiogenesis through inhibiting tyrosine phosphorylation of VEGFR2.
Lu N, Gao Y, Ling Y, Chen Y, Yang Y, Gu HY, Qi Q, Liu W, Wang XT, You QD, Guo QL.
Life Sci 82(17-18):956-63. Epub 2008 Mar 4.PMID: 18378261 2008
46KDR
Polymorphisms of KDR gene are associated with coronary heart disease.
Wang Y, Zheng Y, Zhang W, Yu H, Lou K, Zhang Y, Qin Q, Zhao B, Yang Y, Hui R.
J Am Coll Cardiol 50(8):760-7. Epub 2007 Aug 6. 2007
47FLT1, KDR
Expression of vascular endothelial growth factor receptors is closely related to the histological grade of hepatocellular carcinoma.
Amaoka N, Saio M, Nonaka K, Imai H, Tomita H, Sakashita F, Takahashi T, Sugiyama Y, Takami T, Adachi Y.
Oncol Rep 16(1):3-10. 2006
48FIGF, FLT1, FLT4, KDR, NRP1, NRP2, PGF, VEGFA, VEGFB, VEGFC
Biology of vascular endothelial growth factors.
Roy H, Bhardwaj S, YlŠ-Herttuala S.
FEBS Lett 580(12):2879-87. Epub 2006 Apr 17. 2006
49KDR,LTF,VEGFA
Human lactoferrin upregulates expression of KDR/Flk-1 and stimulates VEGF-A-mediated endothelial cell proliferation and migration.
Kim CW, Son KN, Choi SY, Kim J.
FEBS Lett 580(18):4332-6. Epub 2006 Jul 7. 2006
50KDR, IL6, MMP9
Interleukin-6 triggers human cerebral endothelial cells proliferation and migration: the role for KDR and MMP-9.
Yao JS, Zhai W, Young WL, Yang GY.
Biochem Biophys Res Commun 342(4):1396-404. Epub 2006 Feb 28. 2006
51FLT1,KDR
Differential regulation of vascular endothelial growth factor receptors (VEGFR) revealed by RNA interference: interactions of VEGFR-1 and VEGFR-2 in endothelial cell signaling.
Kou R, SenBanerjee S, Jain MK, Michel T.
Biochemistry 44(45):15064-73. 2005
52KDR
Identification of Flk-1 target genes in vasculogenesis: Pim-1 is required for endothelial and mural cell differentiation in vitro.
Zippo A, De Robertis A, Bardelli M, Galvagni F, Oliviero S.
Blood 103(12):4536-44. Epub 2004 Feb 24. 2004
53TIMP3, VEGFA, KDR
A novel function for tissue inhibitor of metalloproteinases-3 (TIMP3): inhibition of angiogenesis by blockage of VEGF binding to VEGF receptor-2.
Qi JH, Ebrahem Q, Moore N, Murphy G, Claesson-Welsh L, Bond M, Baker A, Anand-Apte B.
Nat Med 9(4):407-15. 2003
54FLT1, KDR, PGF, VEGFA
Role of PlGF in the intra- and intermolecular cross talk between the VEGF receptors Flt1 and Flk1.
Autiero M, Waltenberger J, Communi D, Kranz A, Moons L, Lambrechts D, Kroll J, Plaisance S, De Mol M, Bono F, Kliche S, Fellbrich G, Ballmer-Hofer K, Maglione D, Mayr-Beyrle U, Dewerchin M, Dombrowski S, Stanimirovic D, Van Hummelen P, Dehio C, Hicklin DJ, Persico G, Herbert JM, Communi D, Shibuya M, Collen D, Conway EM, Carmeliet P.
Nat Med 9(7):936-43. 2003
55ADAMTS1, VEGFA, KDR
ADAMTS1/METH1 inhibits endothelial cell proliferation by direct binding and sequestration of VEGF165.
Luque A, Carpizo DR, Iruela-Arispe ML.
J Biol Chem 278(26):23656-65. Epub 2003 Apr 25. 2003
56FBIH, FLT4, KDR
Somatic mutation of vascular endothelial growth factor receptors in juvenile hemangioma.
Walter JW, North PE, Waner M, Mizeracki A, Blei F, Walker JW, Reinisch JF, Marchuk DA.
Genes Chromosomes Cancer 33(3):295-303. 2002
57FLT1, KDR
A repressor sequence in the juxtamembrane domain of Flt-1 (VEGFR-1) constitutively inhibits vascular endothelial growth factor-dependent phosphatidylinositol 3'-kinase activation and endothelial cell migration.
Gille H, Kowalski J, Yu L, Chen H, Pisabarro MT, Davis-Smyth T, Ferrara N.
EMBO J 19(15):4064-4073. 2000
58KDR
Role of alphavbeta3 integrin in the activation of vascular endothelial growth factor receptor-2.
Soldi R, et al.
EMBO J 18 : 882-892. 1999
59KDR
Conditional requirement for the Flk-1 receptor in the in vitro generation of early hematopoietic cells.
Hidaka M, et al.
Proc Natl Acad Sci U S A 96(13):7370-5. 1999
60KDR
KDR Receptor: A Key Marker Defining Hematopoietic Stem Cells.
Ziegler BL, et al.
Science 285(5433):1553-1558. 1999
61KDR
Genomic structure of the human KDR/flk-1 gene.
Yin LY, et al.
Mamm Genome 9 : 408-410. 1998
62KDR
Characterization and kinetic mechanism of catalytic domain of human vascular endothelial growth factor receptor-2 tyrosine kinase (VEGFR2 TK), a key enzyme in angiogenesis.
Parast CV, et al.
Biochemistry 37 : 16788-16801. 1998
63FIGF, FLT1, FLT4, KDR, VEGFA, VEGFB, VEGFC
Vascular endothelial growth factor and its receptors.
Klagsbrun M, D'Amore PA.
Cytokine Growth Factor Rev 7(3):259-70. Review. 1996
64TAPVR1, KDR
A gene for familial total anomalous pulmonary venous return maps to chromosome 4p13-q12.
Bleyl S, et al.
Am J Hum Genet 56 : 408-415. 1995
65KDR
Expression of the vascular endothelial growth factor (VEGF) receptor gene, KDR, in hematopoietic cells and inhibitory effect of VEGF on apoptotic cell death caused by ionizing radiation.
Katoh O, et al.
Cancer Res 55 : 5687-5692. 1995
66KDR
The kinase insert domain receptor gene (KDR) has been relocated to chromosome 4q11-q12.
Sait SNJ, et al.
Cytogenet Cell Genet 70 : 145-146. 1995
67KDR
Cloning and functional analysis of the promoter for KDR/flk-1, a receptor for vascular endothelial growth factor.
Patterson C, Perrella MA, Hsieh CM, Yoshizumi M, Lee ME, Haber E.
J Biol Chem 270(39):23111-8. 1995
68PDGFRA, KDR, KIT, EPHA5
A YAC contig spanning a cluster of human type III receptor protein tyrosine kinase genes (PDGFRA-KIT-KDR) in chromosome segment 4q12.
Spritz RA, et al.
Genomics 22 : 431-436. 1994
69KDR
The KDR gene maps to human chromosome 4q31.2-q32, a locus which is distinct from locations for other type III growth factor receptor tyrosine kinases.
Terman BI, et al.
Cytogenet Cell Genet 60 : 214-215. 1992
70KDR
Identification of a new endothelial cell growth factor receptor tyrosine kinase.
Terman BI, et al.
Oncogene 6 : 1677-1683. 1991
71KDR
A receptor tyrosine kinase cDNA isolated from a population of enriched primitive hematopoietic cells and exhibiting close genetic linkage to c-kit.
Matthews W, et al.
Proc Natl Acad Sci U S A 88 : 9026-9030. 1991
72FLT1, KDR
Nucleotide sequence and expression of a novel human receptor-type tyrosine kinase gene (flt) closely related to the fms family.
Shibuya M, Yamaguchi S, Yamane A, Ikeda T, Tojo A, Matsushime H, Sato M.
Oncogene 5(4):519-24. 1990