| Symbol
| TRIB2
| contributors: mct/pgu - updated : 24-04-2017
|
| HGNC name
| tribbles homolog 2 (Drosophila)
|
| HGNC id
| 30809
|
| Other morbid association(s)
|
| Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
|---|
| tumoral
|
|
| --over
|
|
in acute myelogenous leukemia  | | tumoral
|
|
| --over
|
| |
in primary human lung tumors and in non-small cell lung cancer cells | |
| Susceptibility
|
to multiple sclerosis |
| Variant & Polymorphism
other
| increasing the risk of multiple sclerosis |
| 
|
Candidate gene
Marker
| Therapy target
| may be a promising therapeutic target upon RNAi-mediated TRIB2 knockdown | |
|
| System | Type | Disorder | Pubmed |
|---|
| cancer | | | |
| functional regions that are essential to its oncogenic role provide the basis for developing inhibitors that will block TRIB functions in cancer | | cancer | | | |
| may be a promising therapeutic target upon RNAi-mediated TRIB2 knockdown | | cancer | hemopathy | | |
| represent useful therapeutic targets for the treatment of AML in patients with dys-regulated trb activity |
| | |