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FLASH GENE

Symbol

CNTROB

contributors: mct/pgu - updated : 20-05-2015

HGNC name	centrobin, centrosomal BRCA2 interacting protein
HGNC id	29616

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001037144 19 - 3803 NP_001032221 103.7 925 - 2007 17535851 NM_053051 19 - 3737 NP_444279 101.12 903 - 2007 17535851

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune tonsils         Nervous nerve         Visual eye

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY

CATEGORY

DNA associated

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
text	daughter-centriole-specific, but also found in association with a stable microtubule network of cytoplasm
	recruited to the centriole biogenesis site via its interaction with tubulins during the early stage of centriole biogenesis

basic FUNCTION	has a role in stabilizing the microtubule structure (its phosphorylation may be crucial for mobilization of the protein to a new microtubule and stabilizing it)
	plays an important role in the progression of cell cycle, and a tight association between the cell-cycle progression and defective centrosomes caused by depletion of centrobin
	centrosomal protein that is required for centrosome duplication
	critical for microtubule organization in both interphase and mitotic cells
	centrosome protein required for centriole duplication
	functions as a microtubule stabilizing factor
	is required in maintaining centrosome integrity, which in turn promotes anchoring of mitotic spindle to the centrosomes
	daughter centriole protein that is essential for centrosome duplication
	facilitates the elongation and stability of centrioles via its interaction with tubulins
	centrosome protein for centriole duplication, and also involved in other cellular functions, such as spindle assembly
	might regulate microtubule nucleation and organization by controlling the amount of pericentriolar matrix

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	substrate of NEK2 and its centrosomal localization is controlled by NEK2
	also a substrate of PLK1
	interacts with tubulin directly, and centrobin-tubulin interaction is pivotal for the function of centrobin during centriole duplication
	CNTROB is a substrate of both NEK2 and PLK1 (NEK2 phosphorylation antagonizes the microtubule stabilizing activity of CNTROB)
	CNTROB-CENPJ interaction is critical for the recruitment of CENPJ to procentrioles to promote the elongation of daughter centrioles and for the persistence of CENPJ on preexisting mother centrioles

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene	may represent a novel candidate gene for presently unexplained hereditary forms of teratozoospermia and the "easily decapitated sperm syndrome"
Marker
Therapy target

ANIMAL & CELL MODELS