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FLASH GENE
Symbol ALKBH3 contributors: mct/npt - updated : 26-06-2019
HGNC name alkB, alkylation repair homolog 3 (E. coli)
HGNC id 30141
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies ortholog to murine Alkbh31
Homologene
FAMILY
  • Fe(II)/2OG-dependent dioxygenase superfamily
  • ALKB family
    • CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text in nuclei and cytoplasm
    basic FUNCTION
  • having DNA demethylase activity
  • removing 1-methyladenine and 3-methylcytosine from methylated polynucleotides in an alpha-ketoglutarate-dependent reaction, and act by direct damage reversal with the regeneration of the unsubstituted bases
  • couples substrate oxidation to conversion of 2-oxoglutarate into succinate and CO2
  • ALKBH2-3 and ALKBH7 correct methyl and etheno adducts in DNA
    • CELLULAR PROCESS nucleotide, repair
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Fe(2+) ion per subunit
    • protein
    cell & other
    REGULATION
    activated by ascorbate
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS