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FLASH GENE

Symbol

PDK1

contributors: mct/npt - updated : 06-02-2015

HGNC name	pyruvate dehydrogenase kinase, isozyme 1
HGNC id	8809

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   associated with poor prognosis in head and neck squamous cancer constitutional     --low   in patients with Alzheimer disease compared with nondemented patients

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer hemopathy   PDK1 inhibition could serve as a novel therapeutic approach, in multiple myeloma cancer     PDK1 inhibitors should be investigated for antitumour effects

ANIMAL & CELL MODELS