| 1 | PDK1, PDK2
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| Differing roles of pyruvate dehydrogenase kinases during mouse oocyte maturation.
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| Hou X, Zhang L, Han L, Ge J, Ma R, Zhang X, Moley K, Schedl T, Wang Q.
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| J Cell Sci 128(13):2319-29. doi: 10.1242/jcs.167049. Epub 2015 May 19.
2015
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| 2 | CDC42BPA, PDK1
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| PDK1-mediated activation of MRCKα regulates directional cell migration and lamellipodia retraction.
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| Gagliardi PA, di Blasio L, Puliafito A, Seano G, Sessa R, Chianale F, Leung T, Bussolino F, Primo L.
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| J Cell Biol 206(3):415-34. doi: 10.1083/jcb.201312090.
2014
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| 3 | PDK1
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| PDK1 inhibition is a novel therapeutic target in multiple myeloma.
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| Fujiwara S, Kawano Y, Yuki H, Okuno Y, Nosaka K, Mitsuya H, Hata H.
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| Br J Cancer 108(1):170-8. doi: 10.1038/bjc.2012.527. Epub 2012 Nov 29.
2013
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| 4 | PDK1
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| Overexpression of pyruvate dehydrogenase kinase 1 and lactate dehydrogenase A in nerve cells confers resistance to amyloid β and other toxins by decreasing mitochondrial respiration and reactive oxygen species production.
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| Newington JT, Rappon T, Albers S, Wong DY, Rylett RJ, Cumming RC.
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| J Biol Chem 287(44):37245-58. doi: 10.1074/jbc.M112.366195. Epub 2012 Sep 4.
2012
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| 5 | PDK1
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| Tyrosine phosphorylation of mitochondrial pyruvate dehydrogenase kinase 1 is important for cancer metabolism.
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| Hitosugi T, Fan J, Chung TW, Lythgoe K, Wang X, Xie J, Ge Q, Gu TL, Polakiewicz RD, Roesel JL, Chen GZ, Boggon TJ, Lonial S, Fu H, Khuri FR, Kang S, Chen J.
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| Mol Cell 44(6):864-77. doi: 10.1016/j.molcel.2011.10.015.
2011
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| 6 | BNIP3, PDK1
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| Hypoxia-induced alteration of mitochondrial genes in cardiomyocytes: role of Bnip3 and Pdk1.
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| Jian B, Wang D, Chen D, Voss J, Chaudry I, Raju R.
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| Shock 34(2):169-75. doi: 10.1097/SHK.0b013e3181cffe7d.
2010
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| 7 | PDK1
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| Pyruvate dehydrogenase kinase 1 controls mitochondrial metabolism and insulin secretion in INS-1 832/13 clonal beta-cells.
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| Krus U, Kotova O, Spégel P, Hallgard E, Sharoyko VV, Vedin A, Moritz T, Sugden MC, Koeck T, Mulder H.
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| Biochem J 429(1):205-13. doi: 10.1042/BJ20100142.
2010
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| 8 | PDK1
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| PDK-1 regulates lactate production in hypoxia and is associated with poor prognosis in head and neck squamous cancer.
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| Wigfield SM, Winter SC, Giatromanolaki A, Taylor J, Koukourakis ML, Harris AL.
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| Br J Cancer 98(12):1975-84. Epub 2008 Jun 10.
2008
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| 9 | PDK1
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| Mutation of the PDK1 PH domain inhibits protein kinase B/Akt, leading to small size and insulin resistance.
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| Bayascas JR, Wullschleger S, Sakamoto K, García-Martínez JM, Clacher C, Komander D, van Aalten DM, Boini KM, Lang F, Lipina C, Logie L, Sutherland C, Chudek JA, van Diepen JA, Voshol PJ, Lucocq JM, Alessi DR.
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| Mol Cell Biol 28(10):3258-72. Epub 2008 Mar 17.PMID: 18347057 2008
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| 10 | PDK1
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| Hypoxia-inducible factor 1 and dysregulated c-Myc cooperatively induce vascular endothelial growth factor and metabolic switches hexokinase 2 and pyruvate dehydrogenase kinase 1.
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| Kim JW, Gao P, Liu YC, Semenza GL, Dang CV.
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| Mol Cell Biol 27(21):7381-93. Epub 2007 Sep 4.
2007
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| 11 | PDK1
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| HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia.
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| Kim JW, Tchernyshyov I, Semenza GL, Dang CV.
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| Cell Metab 3(3):177-85.
2006
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| 12 | PDK1
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| Regulation of transforming growth factor-beta signaling and PDK1 kinase activity by physical interaction between PDK1 and serine-threonine kinase receptor-associated protein.
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| Seong HA, Jung H, Choi HS, Kim KT, Ha H.
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| J Biol Chem 280(52):42897-908. Epub 2005 Oct 26. 2005
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| 13 | PDK1, PDK2
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| Formation of functional heterodimers by isozymes 1 and 2 of pyruvate dehydrogenase kinase.
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| Boulatnikov I, Popov KM.
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| Biochim Biophys Acta 1645(2):183-92. 2003
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| 14 | PDK1, PDK2, PDK3
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| Diversity of the pyruvate dehydrogenase kinase gene family in humans.
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| Gudi R, Bowker-Kinley MM, Kedishvili NY, Zhao Y, Popov KM.
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| J Biol Chem 270(48):28989-94. 1995
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