| basic FUNCTION
| stimulator of platelet formation and involved in megakaryocyte growth |
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important growth factor for the megakaryocyte lineage, controlling its proliferation and differentiation |
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playing a proapoptotic role in the brain and contributing to the timing of neuronal selection by the neurotrophins |
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hematopoietic growth factor regulating platelet production  |
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via activation of its receptor-bound JAK2 delays the NGF-dependent acquisition of neuronal phenotype and decreases neuronal survival by suppressing NGF-induced ERK activity |
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activates a number of secondary messengers that promote cell survival, proliferation and differentiation |
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negatively modulates cardiac inotropy and contributes to the myocardial depressing activity of septic shock serum |
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having ability to stimulate platelet production |
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potential role as a physiological regulator of coronary flow |
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with its receptor MPL are essential in the regulation of the hematopoietic stem and progenitors cells as well as for the differentiation of megakaryocytes into mature platelets |
