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FLASH GENE

Symbol

PDPN

contributors: mct - updated : 08-06-2011

HGNC name	podoplanin
HGNC id	29602

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional germinal mutation     loss of function leads to abnormal lung development tumoral     --over   in squamous cell carcinomas, germ cell tumors and colorectal cancer

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

mice with postnatal deletion of Pdpn lost high endothelial venules (HEVs) integrity and exhibited spontaneous bleeding in mucosal lymph nodes, and bleeding in the draining peripheral lymph nodes after immunization