Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol FHOD3 contributors: SGE/shn - updated : 26-05-2010
HGNC name formin homology 2 domain containing 3
HGNC id 26178
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   predominantly
Lymphoid/Immunespleen   highly
Nervousbrain   highly
Urinarykidney   highly
Visualeye   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a DAD domain
  • a FH1 (formin homology 1) domain
  • a FH2 (formin homology 2) domain
  • a GBD/FH3 domain
    • conjugated PhosphoP
    HOMOLOGY
    interspecies ortholog to Fhod3, Mus musculus
    ortholog to FHOD3, Pan troglodytes
    ortholog to Fhod3, Rattus norvegicus
    Homologene
    FAMILY formin homology family
    CATEGORY regulatory , structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microfilament
    text localizes to thin actin filaments in a striated pattern
    basic FUNCTION
  • required for the assembly of f-actin structures, such as stress fibers
  • role in regulation of the actin cytoskeleton (Kanaya et al, 2005)
  • contributing to the coordination of microtubules with actin fibers and playing a role in cell elongation
  • a crucial role in the sarcomere organization of cardiomyocytes (Taniguchi 2009)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule other,
  • interacting with Nestin/NES-based interfilament
    • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS