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FLASH GENE
Symbol FHOD3 contributors: SGE/shn - updated : 26-05-2010
HGNC name formin homology 2 domain containing 3
HGNC id 26178
Location 18q12.2      Physical location : 33.877.701 - 34.360.018
Synonym name
  • FH1/FH2 domain-containing protein 3
  • formin homolog overexpressed in spleen 2
  • formactin 2
    • Synonym symbol(s) FHOS2, KIAA1695, FLJ22297, FLJ22717
    DNA
    TYPE functioning gene
    STRUCTURE 482.32 kb     25 Exon(s)
    MAPPING cloned Y linked N status provisional
    Map cen - D18S1139 - D18S1369 - FHOD3 - D18S1162 - D18S1160 - qter
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    25 - 4942 - 1439 - Kanaya (2005)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   predominantly
    Lymphoid/Immunespleen   highly
    Nervousbrain   highly
    Urinarykidney   highly
    Visualeye   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a DAD domain
  • a FH1 (formin homology 1) domain
  • a FH2 (formin homology 2) domain
  • a GBD/FH3 domain
    • conjugated PhosphoP
    HOMOLOGY
    interspecies ortholog to Fhod3, Mus musculus
    ortholog to FHOD3, Pan troglodytes
    ortholog to Fhod3, Rattus norvegicus
    Homologene
    FAMILY formin homology family
    CATEGORY regulatory , structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microfilament
    text localizes to thin actin filaments in a striated pattern
    basic FUNCTION
  • required for the assembly of f-actin structures, such as stress fibers
  • role in regulation of the actin cytoskeleton (Kanaya et al, 2005)
  • contributing to the coordination of microtubules with actin fibers and playing a role in cell elongation
  • a crucial role in the sarcomere organization of cardiomyocytes (Taniguchi 2009)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule other,
  • interacting with Nestin/NES-based interfilament
    • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS