|
| CLP with mild facial skeletal defects in Rspo2(-/-) mice which also exhibited distal limb loss and lung hypoplasia, and died immediately after birth with respiratory failure; apparent reduction of Wnt/Ctnnb1 signaling activity at the branchial arch and the apical ectodermal ridge in Rspo2(-/-)mice  | |
in Rspo2(-/-) mouse, loss of Rspo2 results in an additional single row of outer hair cells and disruption of peripheral innervation pattern |
|
mice lacking a functional Rspo2 gene exhibit craniofacial abnormalities such as mandibular hypoplasia, maxillary and mandibular skeletal deformation, and cleft palate |