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FLASH GENE
Symbol RSPO2 contributors: mct/npt/pgu - updated : 26-08-2019
HGNC name R-spondin 2 homolog (Xenopus laevis)
HGNC id 28583
ANIMAL & CELL MODELS
  • CLP with mild facial skeletal defects in Rspo2(-/-) mice which also exhibited distal limb loss and lung hypoplasia, and died immediately after birth with respiratory failure; apparent reduction of Wnt/Ctnnb1 signaling activity at the branchial arch and the apical ectodermal ridge in Rspo2(-/-)mice
  • in Rspo2(-/-) mouse, loss of Rspo2 results in an additional single row of outer hair cells and disruption of peripheral innervation pattern
  • mice lacking a functional Rspo2 gene exhibit craniofacial abnormalities such as mandibular hypoplasia, maxillary and mandibular skeletal deformation, and cleft palate