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FLASH GENE

Symbol

LZTR1

contributors: mlc - updated : 25-06-2020

HGNC name	leucine-zipper-like transcriptional regulator, 1
HGNC id	6742

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

NS10

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional   deletion     in DiGeorge syndrome

Susceptibility

to an autosomal dominant inherited disorder of multiple schwannomas

Variant & Polymorphism other	germline loss-of-function mutations in LZTR1 predispose to an inherited disorder of multiple schwannomas

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

Lztr1 deletion in blood vessels of adult mice leads to abnormal vascular leakage