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FLASH GENE
Symbol LZTR1 contributors: mlc - updated : 25-06-2020
HGNC name leucine-zipper-like transcriptional regulator, 1
HGNC id 6742
ASSOCIATED DISORDERS
corresponding disease(s) NS10
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional   deletion    
in DiGeorge syndrome
Susceptibility to an autosomal dominant inherited disorder of multiple schwannomas
Variant & Polymorphism other
  • germline loss-of-function mutations in LZTR1 predispose to an inherited disorder of multiple schwannomas
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Lztr1 deletion in blood vessels of adult mice leads to abnormal vascular leakage