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| in mouse xenograft model treated with chemotherapeutic agent 5-fluorouracil and with murine colon carcinoma cell line CT26 inoculated, Rspo1 treatment substantially reduced 5-FU-induced diarrhea and weight loss | |
zebrafish embryos lacking rspo1 or the proposed rspo1 receptor kremen form primary vessels by vasculogenesis, but are defective in subsequent angiogenesis |
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in XX Rspo1 (-/-) gonads, germ cell proliferation, expression of the early meiotic marker Stra8, and entry into meiosis are all impaired  |