Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol RSPO1 contributors: mct/pgu - updated : 31-03-2018
HGNC name R-spondin homolog (Xenopus laevis)
HGNC id 21679
ANIMAL & CELL MODELS
  • in mouse xenograft model treated with chemotherapeutic agent 5-fluorouracil and with murine colon carcinoma cell line CT26 inoculated, Rspo1 treatment substantially reduced 5-FU-induced diarrhea and weight loss
  • zebrafish embryos lacking rspo1 or the proposed rspo1 receptor kremen form primary vessels by vasculogenesis, but are defective in subsequent angiogenesis
  • in XX Rspo1 (-/-) gonads, germ cell proliferation, expression of the early meiotic marker Stra8, and entry into meiosis are all impaired