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	HGNC	UniGene	Nucleotide	OMIM		UCSC

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FLASH GENE

Symbol

RSPO1

contributors: mct/pgu - updated : 31-03-2018

HGNC name	R-spondin homolog (Xenopus laevis)
HGNC id	21679

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

PPKSR

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --other   aberrantly methylated promoter associated CpG islands in acute lymphocytic leukemia tumoral     --other   potential targets to tackle the complex mammary development and its deregulation with potential links with breast cancers

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed diabete type 2   RSPO1 and the cWnt signaling pathway may serve as a novel target to enhance beta-cell growth and function in patients with type 2 diabetes

ANIMAL & CELL MODELS

	in mouse xenograft model treated with chemotherapeutic agent 5-fluorouracil and with murine colon carcinoma cell line CT26 inoculated, Rspo1 treatment substantially reduced 5-FU-induced diarrhea and weight loss
	zebrafish embryos lacking rspo1 or the proposed rspo1 receptor kremen form primary vessels by vasculogenesis, but are defective in subsequent angiogenesis
	in XX Rspo1 (-/-) gonads, germ cell proliferation, expression of the early meiotic marker Stra8, and entry into meiosis are all impaired