| basic FUNCTION
| may be a crypt cell mitogen protein |
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inducing rapid onset of crypt cell proliferation in the small intestine and colon, involving beta-catenin stabilization |
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may have therapeutic application in gastrointestinal diseases |
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may contribute to the development of dorsal neural tube under the regulation of Wnts |
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playing an essential role in sex determination, skin differentiation and malignancy |
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regulates Wnt signaling by inhibiting internalization of LRP6 |
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antagonizing DKK1 through an interaction with KREMEN1 |
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could have a pivotal role in the suppression or antagonism of testicular determination and differentiation, rather than acting primaily as an ovarian determining gene |
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acting as a crucial regulator of canonical beta-catenin signaling required for female development |
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required to fully suppress the male differentiation program and to maintain germ cell survival during the development of XX gonads |
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may participate in suppressing the male pathway in the absence of Sry and maintaining oocyte survival through positively regulating WNT4 signaling |
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acted synergistically with Wnt3A to activate Wnt/beta-catenin signaling |
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potent and specific mitogen for the gastrointestinal epithelium  |
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having essential roles in vertebrate development and its ligand-type activities overlap substantially with those of the canonical Wnt ligands in that both Rspo and canonical Wnt signaling result in the activation of beta-catenin |
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potentiate Wnt/beta-catenin signaling, an important pathway in embryonic development that is constitutively active in many cancers |
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modulate the Wnt pathway by a common mechanism and coexpression with specific Wnt ligands and DKK1 may determine their biological specificity |
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required for normal development of the mammary gland |
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RSPO1, RSPO2, RSPO3, RSPO4 can stimulate the proliferation of intestinal crypt stem cells, through enhancement of Wnt/CTNNB signaling |
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intestinal growth factor known to exert its effects through activation of the canonical Wnt (cWnt) signaling pathway and subsequent expression of cWnt target genes |
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upregulated in the ovary but not in the testis during critical early stages of gonad development in humans (between 6-9 weeks post conception), and may function as a tissue-specific amplifier of beta-catenin signaling to oppose testis determination |
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activates the WNT/CTNNB signaling pathway in germ cells |
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RSPO1/ CTNNB1 signaling is involved in meiosis in fetal germ cells and contributes to the cellular decision of germ cells to differentiate into oocyte or sperm |
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mimics ZNRF3 inhibition by increasing the membrane level of Wnt receptors |
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enhances Wnt signalling by inhibiting ZNRF3 |
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RSPO1 and WNT4 are two new regulators of cell proliferation in the early gonad regardless of its sex, in addition to the specific role of these genes in ovarian differentiation |
