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FLASH GENE

Symbol

ERBB4

contributors: mct - updated : 03-10-2015

HGNC name	v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)
HGNC id	3432

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

ALS19

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral germinal mutation       juxtamembrane splice variants in same chidhood medulloblastoma tumoral     --over   in lung carcinoma tumoral somatic mutation       in melanoma

Susceptibility

to schizophrenia to left ventricular outflow tract (LVOT) defects

Variant & Polymorphism other	interaction between variants in NRG1 and ERBB4 might contribute to susceptibility for schizophrenia
	a specific haplotype in intron 3 of ERBB4 positively associated with the combined LVOT defects phenotype

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer skin   targeting of ERBB4 with small-molecule inhibitors should be considered as a therapeutic approach for the many individuals with melanoma

ANIMAL & CELL MODELS

astrogenesis occurs precociously in ErbB4 knock-out mice