| 1 | ERBB4, NRG3, PTPN21
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| PTPN21 exerts pro-neuronal survival and neuritic elongation via ErbB4/NRG3 signaling.
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| Plani-Lam JH, Chow TC, Siu KL, Chau WH, Ng MH, Bao S, Ng CT, Sham P, Shum DK, Ingley E, Jin DY, Song YQ.
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| Int J Biochem Cell Biol 61:53-62. doi: 10.1016/j.biocel.2015.02.003. Epub 2015 Feb 11.
2015
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| 2 | CADM1, ERBB3, ERBB4
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| Necl-2/CADM1 interacts with ErbB4 and regulates its activity in GABAergic neurons.
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| Yamada A, Inoue E, Deguchi-Tawarada M, Matsui C, Togawa A, Nakatani T, Ono Y, Takai Y.
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| Mol Cell Neurosci 56C:234-243. doi: 10.1016/j.mcn.2013.06.003. [Epub ahead of print]
2013
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| 3 | ALS19, ERBB4
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| ERBB4 Mutations that Disrupt the Neuregulin-ErbB4 Pathway Cause Amyotrophic Lateral Sclerosis Type 19.
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| Takahashi Y, Fukuda Y, Yoshimura J, Toyoda A, Kurppa K, Moritoyo H, Belzil VV, Dion PA, Higasa K, Doi K, Ishiura H, Mitsui J, Date H, Ahsan B, Matsukawa T, Ichikawa Y, Moritoyo T, Ikoma M, Hashimoto T, Kimura F, Murayama S, Onodera O, Nishizawa M, Yoshida M, Atsuta N, Sobue G; JaCALS, Fifita JA, Williams KL, Blair IP, Nicholson GA, Gonzalez-Perez P, Brown RH Jr, Nomoto M, Elenius K, Rouleau GA, Fujiyama A, Morishita S, Goto J, Tsuji S.
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| Am J Hum Genet 93(5):900-5. doi: 10.1016/j.ajhg.2013.09.008. Epub 2013 Oct 10.
2013
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| 4 | ERBB4, PIAS3
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| Protein inhibitor of activated STAT3 (PIAS3) protein promotes SUMOylation and nuclear sequestration of the intracellular domain of ErbB4 protein.
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| Sundvall M, Korhonen A, Vaparanta K, Anckar J, Halkilahti K, Salah Z, Aqeilan RI, Palvimo JJ, Sistonen L, Elenius K.
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| J Biol Chem 287(27):23216-26. Epub 2012 May 14.
2012
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| 5 | ERBB4, NRG1
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| Neuregulin-1/ErbB4 signaling controls the migration of oligodendrocyte precursor cells during development.
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| Ortega MC, Bribián A, Peregrín S, Gil MT, Marín O, de Castro F.
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| Exp Neurol 235(2):610-20. Epub 2012 Apr 2.
2012
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| 6 | ERBB4
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| Interaction with ErbB4 promotes hypoxia-inducible factor-1α signaling.
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| Paatero I, Jokilammi A, Heikkinen PT, Iljin K, Kallioniemi OP, Jones FE, Jaakkola PM, Elenius K.
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| J Biol Chem 287(13):9659-71. Epub 2012 Feb 3.
2012
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| 7 | ERBB4
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| ErbB4 localization to cardiac myocyte nuclei, and its role in myocyte DNA damage response.
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| Icli B, Bharti A, Pentassuglia L, Peng X, Sawyer DB.
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| Biochem Biophys Res Commun 418(1):116-21. Epub 2012 Jan 5.
2012
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| 8 | BTC, ERBB4
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| Betacellulin promotes cell proliferation in the neural stem cell niche and stimulates neurogenesis.
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| Gómez-Gaviro MV, Scott CE, Sesay AK, Matheu A, Booth S, Galichet C, Lovell-Badge R.
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| Proc Natl Acad Sci U S A 109(4):1317-22. doi: 10.1073/pnas.1016199109. Epub 2012 Jan 9.
2012
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| 9 | ERBB4, NRG1
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| The ERBB4 intracellular domain (4ICD) regulates NRG1-induced gene expression in hippocampal neurons.
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| Allison JG, Das PM, Ma J, Inglis FM, Jones FE.
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| Neurosci Res 70(2):155-63. Epub 2011 Feb 23.
2011
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| 10 | ERBB4
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| Neuregulin receptor ErbB4 functions as a transcriptional cofactor for the expression of surfactant protein B in the fetal lung.
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| Zscheppang K, Dörk T, Schmiedl A, Jones FE, Dammann CE.
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| Am J Respir Cell Mol Biol 45(4):761-7. Epub 2011 Feb 11.
2011
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| 11 | ERBB4
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| Association of common variants in ERBB4 with congenital left ventricular outflow tract obstruction defects.
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| McBride KL, Zender GA, Fitzgerald-Butt SM, Seagraves NJ, Fernbach SD, Zapata G, Lewin M, Towbin JA, Belmont JW.
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| Birth Defects Res A Clin Mol Teratol 91(3):162-8. doi: 10.1002/bdra.20764. Epub 2011 Feb 2.
2011
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| 12 | ERBB4
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| Function of ERBB4 is determined by alternative splicing.
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| Veikkolainen V, Vaparanta K, Halkilahti K, Iljin K, Sundvall M, Elenius K.
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| Cell Cycle 10(16):2647-57. Epub 2011 Aug 15. Review.
2011
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| 13 | DTNA, ERBB2, ERBB4, NRG1
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| Neuregulin/ErbB regulate neuromuscular junction development by phosphorylation of α-dystrobrevin.
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| Schmidt N, Akaaboune M, Gajendran N, Martinez-Pena y Valenzuela I, Wakefield S, Thurnheer R, Brenner HR.
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| J Cell Biol 195(7):1171-84. doi: 10.1083/jcb.201107083. Epub 2011 Dec 19.
2011
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| 14 | ERBB4, NRG1
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| Control of cortical GABA circuitry development by Nrg1 and ErbB4 signalling.
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| Fazzari P, Paternain AV, Valiente M, Pla R, Luján R, Lloyd K, Lerma J, Marín O, Rico B.
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| Nature 464(7293):1376-80. Epub 2010 Apr 14.PMID: 20393464 2010
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| 15 | CNN3, ERBB4
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| h3/Acidic calponin: an actin-binding protein that controls extracellular signal-regulated kinase 1/2 activity in nonmuscle cells.
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| Appel S, Allen PG, Vetterkind S, Jin JP, Morgan KG.
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| Mol Biol Cell 21(8):1409-22. Epub 2010 Feb 24.
2010
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| 16 | ERBB4
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| Cell death or survival promoted by alternative isoforms of ErbB4.
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| Sundvall M, Veikkolainen V, Kurppa K, Salah Z, Tvorogov D, van Zoelen EJ, Aqeilan R, Elenius K.
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| Mol Biol Cell 21(23):4275-86. Epub 2010 Oct 13.
2010
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| 17 | ERBB4
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| Molecular cloning and characterization of the human ErbB4 gene: identification of novel splice isoforms in the developing and adult brain.
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| Tan W, Dean M, Law AJ.
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| PLoS One 5(9):e12924.
2010
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| 18 | ERBB4, WWP1
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| WW domain containing E3 ubiquitin protein ligase 1 targets the full-length ErbB4 for ubiquitin-mediated degradation in breast cancer.
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| Li Y, Zhou Z, Alimandi M, Chen C.
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| Oncogene 28(33):2948-58. Epub 2009 Jun 29.
2009
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| 19 | ERBB4
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| Analysis of the tyrosine kinome in melanoma reveals recurrent mutations in ERBB4.
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| Prickett TD, Agrawal NS, Wei X, Yates KE, Lin JC, Wunderlich JR, Cronin JC, Cruz P, Rosenberg SA, Samuels Y.
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| Nat Genet 41(10):1127-32. Epub 2009 Aug 30.PMID: 19718025 2009
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| 20 | ERBB4
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| Isoform-specific monoubiquitination, endocytosis, and degradation of alternatively spliced ErbB4 isoforms.
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| Sundvall M, Korhonen A, Paatero I, Gaudio E, Melino G, Croce CM, Aqeilan RI, Elenius K.
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| Proc Natl Acad Sci U S A 105(11):4162-7. Epub 2008 Mar 11. 2008
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| 21 | APC, ATM, EPHA3, ERBB2, ERBB4, FGFR4
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| Somatic mutations affect key pathways in lung adenocarcinoma.
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| Ding L, Getz G, Wheeler DA, Mardis ER, McLellan MD, Cibulskis K, Sougnez C, Greulich H, Muzny DM, Morgan MB, Fulton L, Fulton RS, Zhang Q, Wendl MC, Lawrence MS, Larson DE, Chen K, Dooling DJ, Sabo A, Hawes AC, Shen H, Jhangiani SN, Lewis LR, Hall O, Zhu Y, Mathew T, Ren Y, Yao J, Scherer SE, Clerc K, Metcalf GA, Ng B, Milosavljevic A, Gonzalez-Garay ML, Osborne JR, Meyer R, Shi X, Tang Y, Koboldt DC, Lin L, Abbott R, Miner TL, Pohl C, Fewell G, Haipek C, Schmidt H, Dunford-Shore BH, Kraja A, Crosby SD, Sawyer CS, Vickery T, Sander S, Robinson J, Winckler W, Baldwin J, Chirieac LR, Dutt A, Fennell T, Hanna M, Johnson BE, Onofrio RC, Thomas RK, Tonon G, Weir BA, Zhao X, Ziaugra L, Zody MC, Giordano T, Orringer MB, Roth JA, Spitz MR, Wistuba II, Ozenberger B, Good PJ, Chang AC, Beer DG, Watson MA, Ladanyi M, Broderick S, Yoshizawa A, Travis WD, Pao W, Province MA, Weinstock GM, Varmus HE, Gabriel SB, Lander ES, Gibbs RA, Meyerson M, Wilson RK.
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| Nature 455(7216):1069-75.
2008
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| 22 | ERBB4, NRG1
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| Association and interaction analyses of NRG1 and ERBB4 genes with schizophrenia in a Japanese population.
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| Shiota S, Tochigi M, Shimada H, Ohashi J, Kasai K, Kato N, Tokunaga K, Sasaki T.
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| J Hum Genet 53(10):929-35. Epub 2008 Aug 14.
2008
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| 23 | EGFR, ERBB2, ERBB3, ERBB4
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| N-glycan of ErbB family plays a crucial role in dimer formation and tumor promotion.
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| Takahashi M, Yokoe S, Asahi M, Lee SH, Li W, Osumi D, Miyoshi E, Taniguchi N.
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| Biochim Biophys Acta 1780(3):520-4. Epub 2007 Nov 6.PMID: 18036567 2008
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| 24 | EGFR, ERBB2, ERBB3, ERBB4
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| Characterization of a novel tripartite nuclear localization sequence in the EGFR family.
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| Hsu SC, Hung MC.
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| J Biol Chem 282(14):10432-40. Epub 2007 Feb 5. 2007
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| 25 | ERBB4
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| Presenilin-dependent ErbB4 nuclear signaling regulates the timing of astrogenesis in the developing brain.
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| Sardi SP, Murtie J, Koirala S, Patten BA, Corfas G.
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| Cell 127(1):185-97. 2006
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| 26 | ERBB4
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| Alternative splicing of the ErbB-4 cytoplasmic domain and its regulation by hedgehog signaling identify distinct medulloblastoma subsets.
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| Ferretti E, Di Marcotullio L, Gessi M, Mattei T, Greco A, Po A, De Smaele E, Giangaspero F, Riccardi R, Di Rocco C, Pazzaglia S, Maroder M, Alimandi M, Screpanti I, Gulino A.
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| Oncogene 25(55):7267-73. Epub 2006 Jul 31. 2006
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| 27 | PPP2R4, ERBB4
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| Expression of the ErbB4 receptor causes reversal regulation of PP2A in the Shc signal transduction pathway in human cancer cells.
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| Yumoto N, Yu X, Hatakeyama M.
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| Mol Cell Biochem 285(1-2):165-71. Epub 2006 Feb 14. 2006
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| 28 | ERBB2, ERBB4
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| Synapses form in skeletal muscles lacking neuregulin receptors.
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| Escher P, Lacazette E, Courtet M, Blindenbacher A, Landmann L, Bezakova G, Lloyd KC, Mueller U, Brenner HR.
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| Science 308(5730):1920-3. 2005
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| 29 | ERBB4, STAT5A
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| ERBB4/HER4 potentiates STAT5A transcriptional activity by regulating novel STAT5A serine phosphorylation events.
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| Clark DE, Williams CC, Duplessis TT, Moring KL, Notwick AR, Long W, Lane WS, Beuvink I, Hynes NE, Jones FE.
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| J Biol Chem 280(25):24175-80. Epub 2005 Apr 29. 2005
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| 30 | NRG1, NRG2, NRG3, ERBB2, ERBB3, ERBB4, EGFR
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| Neuregulin promotes autophagic cell death of prostate cancer cells.
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| Tal-Or P, Di-Segni A, Lupowitz Z, Pinkas-Kramarski R.
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| Prostate 55(2):147-57. 2003
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| 31 | ERBB4
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| Novel ERBB4 juxtamembrane splice variants are frequently expressed in childhood medulloblastoma.
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| Gilbertson R, Hernan R, Pietsch T, Pinto L, Scotting P, Allibone R, Ellison D, Perry R, Pearson A, Lunec J.
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| Genes Chromosomes Cancer 31(3):288-94. 2001
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| 32 | DLG4, ERBB4, PSD95
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| The neuregulin receptor ErbB-4 interacts with PDZ-containing proteins at neuronal synapses.
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| Garcia RA, Vasudevan K, Buonanno A.
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| Proc Natl Acad Sci U S A 97(7):3596-601. 2000
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| 33 | ERBB4
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| Localization of the human HER4/erbB-4 gene to chromosome 2.
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| Zimonjic DB, et al.
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| Oncogene 10 : 1235-1237. 1995
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| 34 | ERBB2, ERBB3, ERBB4
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| ErbB-3 and ErbB-4 function as the respective low and high affinity receptors of all Neu differentiation factor/heregulin isoforms.
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| Tzahar E, Levkowitz G, Karunagaran D, Yi L, Peles E, Lavi S, Chang D, Liu N, Yayon A, Wen D, et al.
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| J Biol Chem 269(40):25226-33. 1994
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| 35 | ERBB4
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| Ligand-specific activation of HER4/p180erbB4, a fourth member of the epidermal growth factor receptor family.
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| Plowman GD, et al.
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| Proc Natl Acad Sci U S A 90 : 1746-1750. 1993
|