| Symbol
| IGF2BP1
| contributors: mct/pgu - updated : 09-07-2013
|
| HGNC name
| insulin-like growth factor 2 mRNA binding protein 1
|
| HGNC id
| 28866
|
| Other morbid association(s)
|
| Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
|---|
| tumoral
|
|
|
|
|
amplified in breast cancer  | | tumoral
|
|
| --over
|
| |
overexpressed in primary malignant melanomas | | tumoral
|
|
| --over
|
| |
observed preferentially in high-grade and high-stage cases and significant prognostic indicator for reduced recurrence-free and overall survival | | tumoral
|
|
| --other
|
| |
aberrant expression in diffuse large B-cell | |
Variant & Polymorphism
| 
| |
Candidate gene
| Marker
| prognostic biomarker for lung cancer | Therapy target
|
|
| System | Type | Disorder | Pubmed |
|---|
| cancer | skin | | |
| knockdown of IGF2BP1 inhibits NF-KappaB activity, induces apoptosis and suppresses proliferation and tumorigenic properties of melanoma cells | | cancer | lung | | |
| promising therapeutic target for lung cancer |
| | |