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FLASH GENE

Symbol

S100P

contributors: mct - updated : 24-03-2020

HGNC name	S100 calcium binding protein P
HGNC id	10504

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   by hypomethylation in prostate cancer (Wang 2007) tumoral     --low   in lung adenocarcinomas, at advanced stages seems to be important for tumour progression in which DNA methylation and/or feedback transcription processes play a critical role tumoral     --over   in highly metastatic cancers is probably due to a direct interaction between S100P-ezrin tumoral     --over   in human hepatocellular carcinoma (HCC)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	analysis of S100P concentration in Duodenal Fluid, in combination with routine screening upper gastrointestinal endoscopy (GIE), may facilitate the detection of pancreatic ductal adenocarcinoma (PDAC)
	plasma S100P level is a simple and cost-effective marker for the prognosis of metastatic breast cancer
	S100P may be regarded as a promising diagnostic marker to Pancreatic cancer screening
	S100P protein is a novel independent predictor for poor prognosis in HCC
	may be used as a unique biomarker of the receptive endometrium and play an important role in embryo implantation
Therapy target
	System Type Disorder Pubmed cancer metastases   S100P may be a promising target to inhibit lymph node metastasis

ANIMAL & CELL MODELS