Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol S100P contributors: mct - updated : 24-03-2020
HGNC name S100 calcium binding protein P
HGNC id 10504
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one classical EF-hand Ca2+-binding domain and an atypical EF-hand domain
  • AAs 21–25 of the first EF hand of S100P as important for IQGAP1 binding
  • C-terminal lysine residue, and strong, C-terminal lysine-dependent activation of tissue plasminogen activator (PLAT), but not of urokinase-catalysed plasminogen activation
    • mono polymer monomer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • S100 protein family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm,nuclear bodies
    basic FUNCTION
  • involved in cell cycle progression and differentiation
  • can activate the membrane and F-actin binding protein ezrin in a Ca2+ dependent manner
  • affects apoptosis, cell growth, and invasion through either an intracellular or an extracellular mechanism
  • Ca2+-dependent regulator of IQGAP1 that can down-regulate the function of IQGAP1 as a signaling intermediate by direct interaction
  • appears to regulate only a set of IQGAP1-target protein interactions in response to intracellular Ca2+ transients
  • S100P participates in the periodic change of the endometrium under the regulation of progesterone
  • may have a physiological role in normal pregnant development, and regulate trophoblast-like cell proliferation via modulating the MAPK14 pathway
  • Ca2+ binding protein, overexpressed in various cancers, that increases cancer migration, invasion and metastasis in lung cancer cells
  • is a small calcium-binding protein in the S100 protein family that regulates cellular, physiological and pathological processes in various cancers
  • S100P may be acting as an important regulator of trophoblast invasion during placentation
  • S100P and EZR promote trans-endothelial migration of triple negative breast cancer cells
  • contribute to a cancer pathway dependent on the context of CDH1 function
  • S100P has a dual role in gastric cancer, acting as an oncogenic factor in the context of CDH1 loss and as a tumour suppressor in a functional CDH1 setting
    • CELLULAR PROCESS cell life, differentiation
    cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • both dimeric and monomeric forms of S100P can be functional
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with IQGAP1 (binding occurs primarily through the IQ domain of IQGAP1 and the first EF hand loop of S100P)
  • S100P dissociates MYH9 filaments and focal adhesion sites to reduce cell adhesion and enhance cell migration
  • SOX9 promotes tumor metastasis and invasion through regulation of S100P expression
  • interacts with ITGA7 and increases cancer cell migration and invasion in lung cancer
  • LASP1 may act as an oncogene to regulate the expression of S100P to influence cellular functions in gallbladder cancer (GBC)
  • S100P protein interacts with interferon beta (IFNB1) depending on calcium level and oligomeric state of S100P
  • S100P can interact directly with two different cytoskeletal filaments to independently enhance cell migration, the most important step in the metastatic cascade
    • cell & other
    REGULATION
    activated by non-steroidal anti-inflammatory drugs, which reduces their anti-tumorigenic activity
    Other regulated by PORCN (might regulate the expression of some cancer-related molecules including S100P in non-small cell lung carcinoma)
    regulated by bone morphogenetic protein in pancreatic duct epithelial cell lines
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    by hypomethylation in prostate cancer (Wang 2007)
    tumoral     --low  
    in lung adenocarcinomas, at advanced stages seems to be important for tumour progression in which DNA methylation and/or feedback transcription processes play a critical role
    tumoral     --over  
    in highly metastatic cancers is probably due to a direct interaction between S100P-ezrin
    tumoral     --over  
    in human hepatocellular carcinoma (HCC)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • analysis of S100P concentration in Duodenal Fluid, in combination with routine screening upper gastrointestinal endoscopy (GIE), may facilitate the detection of pancreatic ductal adenocarcinoma (PDAC)
  • plasma S100P level is a simple and cost-effective marker for the prognosis of metastatic breast cancer
  • S100P may be regarded as a promising diagnostic marker to Pancreatic cancer screening
  • S100P protein is a novel independent predictor for poor prognosis in HCC
  • may be used as a unique biomarker of the receptive endometrium and play an important role in embryo implantation
    • Therapy target
    SystemTypeDisorderPubmed
    cancermetastases 
    S100P may be a promising target to inhibit lymph node metastasis
    ANIMAL & CELL MODELS