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FLASH GENE

Symbol

S100P

contributors: mct - updated : 24-03-2020

HGNC name	S100 calcium binding protein P
HGNC id	10504

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_005980 2 - 510 NP_005971 - 95 - 1992 1633809

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Digestive intestine large intestine colon       stomach         Reproductive female system uterus cervix     Respiratory lung         Urinary bladder

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text	placenta and is expressed in trophoblasts, the highest expression levels occurring during the first trimester of gestation, particularly in the invading columns and anchoring villi

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	one classical EF-hand Ca2+-binding domain and an atypical EF-hand domain
	AAs 21–25 of the first EF hand of S100P as important for IQGAP1 binding
	C-terminal lysine residue, and strong, C-terminal lysine-dependent activation of tissue plasminogen activator (PLAT), but not of urokinase-catalysed plasminogen activation

mono polymer

monomer , dimer

HOMOLOGY

Homologene

FAMILY

S100 protein family

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nucleus,nucleoplasm,nuclear bodies

basic FUNCTION	involved in cell cycle progression and differentiation
	can activate the membrane and F-actin binding protein ezrin in a Ca2+ dependent manner
	affects apoptosis, cell growth, and invasion through either an intracellular or an extracellular mechanism
	Ca2+-dependent regulator of IQGAP1 that can down-regulate the function of IQGAP1 as a signaling intermediate by direct interaction
	appears to regulate only a set of IQGAP1-target protein interactions in response to intracellular Ca2+ transients
	S100P participates in the periodic change of the endometrium under the regulation of progesterone
	may have a physiological role in normal pregnant development, and regulate trophoblast-like cell proliferation via modulating the MAPK14 pathway
	Ca2+ binding protein, overexpressed in various cancers, that increases cancer migration, invasion and metastasis in lung cancer cells
	is a small calcium-binding protein in the S100 protein family that regulates cellular, physiological and pathological processes in various cancers
	S100P may be acting as an important regulator of trophoblast invasion during placentation
	S100P and EZR promote trans-endothelial migration of triple negative breast cancer cells
	contribute to a cancer pathway dependent on the context of CDH1 function
	S100P has a dual role in gastric cancer, acting as an oncogenic factor in the context of CDH1 loss and as a tumour suppressor in a functional CDH1 setting

CELLULAR PROCESS	cell life, differentiation
	cell life, proliferation/growth

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

both dimeric and monomeric forms of S100P can be functional

INTERACTION

DNA

RNA

small molecule

protein	interacting with IQGAP1 (binding occurs primarily through the IQ domain of IQGAP1 and the first EF hand loop of S100P)
	S100P dissociates MYH9 filaments and focal adhesion sites to reduce cell adhesion and enhance cell migration
	SOX9 promotes tumor metastasis and invasion through regulation of S100P expression
	interacts with ITGA7 and increases cancer cell migration and invasion in lung cancer
	LASP1 may act as an oncogene to regulate the expression of S100P to influence cellular functions in gallbladder cancer (GBC)
	S100P protein interacts with interferon beta (IFNB1) depending on calcium level and oligomeric state of S100P
	S100P can interact directly with two different cytoskeletal filaments to independently enhance cell migration, the most important step in the metastatic cascade

cell & other

REGULATION

activated by

non-steroidal anti-inflammatory drugs, which reduces their anti-tumorigenic activity

Other	regulated by PORCN (might regulate the expression of some cancer-related molecules including S100P in non-small cell lung carcinoma)
	regulated by bone morphogenetic protein in pancreatic duct epithelial cell lines

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   by hypomethylation in prostate cancer (Wang 2007) tumoral     --low   in lung adenocarcinomas, at advanced stages seems to be important for tumour progression in which DNA methylation and/or feedback transcription processes play a critical role tumoral     --over   in highly metastatic cancers is probably due to a direct interaction between S100P-ezrin tumoral     --over   in human hepatocellular carcinoma (HCC)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	analysis of S100P concentration in Duodenal Fluid, in combination with routine screening upper gastrointestinal endoscopy (GIE), may facilitate the detection of pancreatic ductal adenocarcinoma (PDAC)
	plasma S100P level is a simple and cost-effective marker for the prognosis of metastatic breast cancer
	S100P may be regarded as a promising diagnostic marker to Pancreatic cancer screening
	S100P protein is a novel independent predictor for poor prognosis in HCC
	may be used as a unique biomarker of the receptive endometrium and play an important role in embryo implantation
Therapy target
	System Type Disorder Pubmed cancer metastases   S100P may be a promising target to inhibit lymph node metastasis

ANIMAL & CELL MODELS