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FLASH GENE
Symbol TNS4 contributors: mct/ - updated : 28-08-2015
HGNC name tensin 4
HGNC id 24352
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • six potential tyrosine phosphorylation sites
  • an Src homology (SH) 2 and a phosphotyrosine-binding (PTB) domain that allows it to interact with the cytoplasmic tail of the beta-integrins
  • two independent focal adhesion binding sites
  • C-terminal tandem SH2-PTB domain pairing
    • HOMOLOGY
    Homologene
    FAMILY
  • tensin family
    • CATEGORY signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton
    intracellular,nucleus
    text
  • localization at focal adhesions and/or in the cytoplasm; in addition, has been detected in the nucleus
    • basic FUNCTION
  • involved in intracellular signaling cascade
  • thought to act as links between the extracellular matrix and the cytoskeleton, and thereby mediate signaling for cell shape and motility
  • large intracellular proteins believed to link the extracellular matrix to the cytoskeleton via integrins
  • focal adhesion protein that play important roles in signal transduction and cytoskeletal reorganization
  • role of the TNS4-STAT3 axis in epithelial sheet invasion and tubulogenesis
  • in the colon and pancreas, is a downstream target of KRAS and may be a mechanism through which KRAS regulates of cell motility
  • oncogenic role in pancreatic cancer through promotion of colony formation and cell motility
  • function for TNS4 in prolonging signaling from EGFR by reducing its ligand-induced degradation
  • nuclear TNS4 contributes likely to cancer cell proliferation
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • regulation of the Rho-GAP activity of DLC1 by TNS3 and TNS4 controls EGF-driven cell migration and transformation
  • regulates EGFR protein levels through a posttranslational mechanism
  • TNS4 recruits signaling molecules, such as DLC1, to focal adhesions, modulates homeostasis of receptor tyrosine kinases, including EGFR and MET, and promotes cell migration
  • nuclear exporting of TNS4 is a XPO1-dependent process
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    or nul in prostate cancers and prostate cancer cell lines
    tumoral     --over  
    in 70 p100 of pancreatic cancers
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • its expression is of prognostic significance in colorectal cancer, delineating a TNS4-ILK pathway controlling cell motility and possibly promoting metastasis
    • Therapy target
    SystemTypeDisorderPubmed
    cancermetastases 
    anti-metastatic therapies may benefit from restoring or preserving tensin expression in primary tumors
    ANIMAL & CELL MODELS