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FLASH GENE
Symbol PHB2 contributors: mct/npt/pgu - updated : 24-10-2017
HGNC name prohibitin 2
HGNC id 30306
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated PhosphoP
HOMOLOGY
interspecies ortholog to rattus Bcap37
ortholog to murine Bcap37
Homologene
FAMILY
  • prohibitin family
    • CATEGORY regulatory , transcription factor , receptor nuclear
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,membrane
    intracellular,nucleus
    text
  • present in various cellular compartments including the nucleus
    • basic FUNCTION
  • repressor of estrogen receptor activity
  • negative regulation of transcription
  • mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases
  • playing a role in regulating mitochondrial respiratory activity and in aging
  • phosphoprotein up-regulated during T cell activation that function to maintain mitochondrial integrity
  • having diverse functions, such as the regulation of apoptosis and the maintenance of mitochondrial morphology
  • membrane protein that is essential for cell proliferation and development in higher eukaryotes
    • CELLULAR PROCESS cell life
    nucleotide, transcription, regulation
    cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism nucleic
    signaling
    DNA metabolism
    a component
  • prohibitin-1 (PHB) and prohibitin-2 (PHB2), form large, multimeric ring complexes in the inner membrane of mitochondria
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PHB/PHB1
  • HDAC1
  • interacting with RNF2 and TFCP2 (RNF2 and PHB2 modulate the TFCP2-mediated transcriptional pathway)
  • interacts with AKT1 and inhibits muscle differentiation by repressing the transcriptional activity of both MYOD1 and MEF2C
  • CAMK4 specifically binds to the C terminus of PHB2 and phosphorylates PHB2 at serine 91
  • PHB/PHB2 and the CD86 cytoplasmic domain cooperate to mediate CD86 signaling in a B cell through differential phosphorylation of distal signaling intermediates required to increase IGHG1
  • SIGLEC9 bound to prohibitins PHB, PHB2, in a sialic acid-independent manner
    • cell & other
    REGULATION
    induced by metabolic stress caused by an imbalance in the synthesis of mitochondrial- and nuclear-encoded mitochondrial proteins
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS