Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol IFNAR2 contributors: mct - updated : 08-03-2013
HGNC name interferon (alpha, beta and omega) receptor 2
HGNC id 5433
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • IFNAR2 intracellular domain (IFNaR2-ICD) can mediate gene transcription in a STAT2 dependent manner, and liberation of the IFNAR2-ICD by regulated proteolysis could trigger a novel mechanism for moving the transcription factor STAT2 to the nucleus
    • HOMOLOGY
    Homologene
    FAMILY cytokin receptor family II
    CATEGORY receptor
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,endosome
    text shortly after IFN stimulation, a small amount of IFNAR2 were found in the endosomal compartment
    basic FUNCTION
  • subunit of the interferon receptor, can be proteolytically cleaved in response to interferon-alpha and other activators of protein kinase C
  • trafficking of the IFN receptor (IFNAR1 and IFNAR2) through endosomes may potentially regulate signaling pathways
  • may play an important role in determining IFN response and clinical phenotypes of HBV infection
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds JAK1 and STAT2
  • nuclear transit of the intracellular domain of the interferon receptor subunit IFNAR2 requires STAT2 and IRF9
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) IMD45
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in the primary renal cell carcinoma in patients with metastases compared to those without
    constitutional     --over  
    in Alzheimer Disease
    tumoral     --over  
    associated with lung cancers that behave aggressively
    Susceptibility
  • susceptibility to chronic HBV infection
    • Variant & Polymorphism SNP
  • IFNAR2-F8S polymorphisms might be involved in the susceptibility to chronic HBV infection
    • Candidate gene
    Marker
  • prognostic biomarker for lung cancer
    • Therapy target
    ANIMAL & CELL MODELS