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FLASH GENE
Symbol IFNAR2 contributors: mct - updated : 08-03-2013
HGNC name interferon (alpha, beta and omega) receptor 2
HGNC id 5433
DNA
TYPE functioning gene
STRUCTURE 34.62 kb     9 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
RNA
TRANSCRIPTS type messenger
text two membrane bound forms, beta L(1010kDa) subunit and beta S (55kDa) (Domanski)
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 - 2898 - 515 - 2007 17095088
9 - 1428 - 331 - 2007 17095088
9 - 1382 - 331 - 2007 17095088
9 - 2966 - 515 - 2007 17095088
8 - 2835 - 239 - 2007 17095088
8 - 2789 - 239 - 2007 17095088
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Lymphoid/Immunespleen   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Connectiveadipose  highly
Connectivebone   
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticmonocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • IFNAR2 intracellular domain (IFNaR2-ICD) can mediate gene transcription in a STAT2 dependent manner, and liberation of the IFNAR2-ICD by regulated proteolysis could trigger a novel mechanism for moving the transcription factor STAT2 to the nucleus
  • HOMOLOGY
    Homologene
    FAMILY cytokin receptor family II
    CATEGORY receptor
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,endosome
    text shortly after IFN stimulation, a small amount of IFNAR2 were found in the endosomal compartment
    basic FUNCTION
  • subunit of the interferon receptor, can be proteolytically cleaved in response to interferon-alpha and other activators of protein kinase C
  • trafficking of the IFN receptor (IFNAR1 and IFNAR2) through endosomes may potentially regulate signaling pathways
  • may play an important role in determining IFN response and clinical phenotypes of HBV infection
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds JAK1 and STAT2
  • nuclear transit of the intracellular domain of the interferon receptor subunit IFNAR2 requires STAT2 and IRF9
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) IMD45
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in the primary renal cell carcinoma in patients with metastases compared to those without
    constitutional     --over  
    in Alzheimer Disease
    tumoral     --over  
    associated with lung cancers that behave aggressively
    Susceptibility
  • susceptibility to chronic HBV infection
  • Variant & Polymorphism SNP
  • IFNAR2-F8S polymorphisms might be involved in the susceptibility to chronic HBV infection
  • Candidate gene
    Marker
  • prognostic biomarker for lung cancer
  • Therapy target
    ANIMAL & CELL MODELS