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FLASH GENE
Symbol MAT2A contributors: mct - updated : 27-01-2015
HGNC name methionine adenosyltransferase II, alpha
HGNC id 6904
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer homomer , dimer
HOMOLOGY
interspecies homolog to C.elegans C06e7.1
Homologene
FAMILY ADOMET synthetase family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytosolic
basic FUNCTION
  • catalyzes the production of S-adenosylmethionine from methionine and ATP, which plays a pivotal role in the methylation of neurotransmitters, DNA, proteins, and lipids
  • catalyzes the transfer of the adenosyl moiety from ATP to L-methionine to synthesize S-adenosylmethionine (SAM)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism aminoacid
    signaling
    activated methyl cycle
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor,
  • binds 2 divalent ions per subunit, magnesium or cobalt
  • binds 1 potassium ion per subunit
    • protein
  • transcription factor SP1 seems to play a decisive role in MAT2A induction, as it binds the promoter when the gene is being actively transcribed (
  • serves as a transcriptional corepressor of MAF oncoprotein
  • interacts with histone methyltransferase SETDB1 and inhibits PTGS2 gene expression
    • cell & other
    REGULATION
    Other phosphorylation of MAT2A, MAT2B proteins during hepatic stellate cells (HSCs) activation stabilizes them thereby positively regulating trans-differentiation
    its enzymatic activity is regulated by an associated subunit MAT2B
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to familial thoracic aortic aneurysms and dissections (FTAAD)
    Variant & Polymorphism other
  • MAT2A mutations are a rare cause of FTAAD
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS