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FLASH GENE

Symbol

CD86

contributors: mct - updated : 24-10-2017

HGNC name	CD86 antigen (CD28 antigen ligand 2, B7-2 antigen)
HGNC id	1705

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional       gain of function or expressed aberrantly on immune cells in a wide array of autoimmune and infectious diseases constitutional     --low   of CD86 expression by transitional B-cells due to the autocrine effect of IL10, which in turn leads to decreased T-cell proliferation and TNF production

Susceptibility

to asthma

Variant & Polymorphism other	I179V polymorphism, may be a novel aetiological factor in the development of asthma and related allergic disorders

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS