| 1 | CD1D, CD86
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| Decreased CD1d level is associated with CD86 over-expression in B cells from systemic lupus erythematosus.
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| Liu F, Ji J, Li X, Li X, Xu J, Yue H, Zhao S, Fan H, Hou Y.
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| Acta Biochim Biophys Sin (Shanghai) 49(4):328-337. doi: 10.1093/abbs/gmx011.
2017
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| 2 | CD86
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| IL-10-produced by human transitional B-cells down-regulates CD86 expression on B-cells leading to inhibition of CD4+T-cell responses.
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| Nova-Lamperti E, Fanelli G, Becker PD, Chana P, Elgueta R, Dodd PC, Lord GM, Lombardi G, Hernandez-Fuentes MP.
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| Sci Rep 6:20044. doi: 10.1038/srep20044.
2016
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| 3 | CD86, DEF103B, P2RX7
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| Human β Defensin-3 Increases CD86 Expression on Monocytes by Activating the ATP-Gated Channel P2X7.
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| Lioi AB, Ferrari BM, Dubyak GR, Weinberg A, Sieg SF.
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| J Immunol 195(9):4438-45. doi: 10.4049/jimmunol.1401319. Epub 2015 Sep 28.
2015
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| 4 | CD80, CD86
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| CD80 and CD86 IgC domains are important for quaternary structure, receptor binding and co-signaling function.
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| Girard T, Gaucher D, El-Far M, Breton G, Sékaly RP.
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| Immunol Lett 161(1):65-75. doi: 10.1016/j.imlet.2014.05.002. Epub 2014 May 15.
2014
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| 5 | CD86, IL21
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| IL-21 promotes CD4 T cell responses by phosphatidylinositol 3-kinase-dependent upregulation of CD86 on B cells.
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| Attridge K, Kenefeck R, Wardzinski L, Qureshi OS, Wang CJ, Manzotti C, Okkenhaug K, Walker LS.
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| J Immunol 192(5):2195-201. doi: 10.4049/jimmunol.1302082. Epub 2014 Jan 27.
2014
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| 6 | CD80, CD86, IL6
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| Novel regulation of CD80/CD86-induced phosphatidylinositol 3-kinase signaling by NOTCH1 protein in interleukin-6 and indoleamine 2,3-dioxygenase production by dendritic cells.
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| Koorella C, Nair JR, Murray ME, Carlson LM, Watkins SK, Lee KP.
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| J Biol Chem 289(11):7747-62. doi: 10.1074/jbc.M113.519686. Epub 2014 Jan 10.
2014
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| 7 | CD80, CD86
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| Differential DNA methylation patterns in the CD86 gene controls its constitutive expression in keratinocytes.
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| Romero-Tlalolini MA, Chávez Olmos P, Garrido E.
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| Biochem Biophys Res Commun 438(1):54-60. doi: 10.1016/j.bbrc.2013.07.023. Epub 2013 Jul 16.
2013
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| 8 | CD86, IGHG1, PHB, PHB2
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| Prohibitins and the cytoplasmic domain of CD86 cooperate to mediate CD86 signaling in B lymphocytes.
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| Lucas CR, Cordero-Nieves HM, Erbe RS, McAlees JW, Bhatia S, Hodes RJ, Campbell KS, Sanders VM.
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| J Immunol 190(2):723-36. doi: 10.4049/jimmunol.1201646. Epub 2012 Dec 12.
2013
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| 9 | CD86
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| A conserved polylysine motif in CD86 cytoplasmic tail is necessary for cytoskeletal association and effective co-stimulation.
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| Girard T, El-Far M, Gaucher D, Acuto O, Beaulé G, Michel F, Mourad W, Sékaly RP.
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| Biochem Biophys Res Commun 423(2):301-7. doi: 10.1016/j.bbrc.2012.05.116. Epub 2012 May 30.
2012
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| 10 | CD86, IL2, NFATC1
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| IL-2 upregulates CD86 expression on human CD4(+) and CD8(+) T cells.
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| Paine A, Kirchner H, Immenschuh S, Oelke M, Blasczyk R, Eiz-Vesper B.
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| J Immunol 188(4):1620-9. doi: 10.4049/jimmunol.1100181. Epub 2012 Jan 13.
2012
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| 11 | CD86, MARCHF1
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| Ubiquitination of CD86 is a key mechanism in regulating antigen presentation by dendritic cells.
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| Baravalle G, Park H, McSweeney M, Ohmura-Hoshino M, Matsuki Y, Ishido S, Shin JS.
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| J Immunol 187(6):2966-73. Epub 2011 Aug 17. 2011
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| 12 | CD86, MARCHF1
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| Ubiquitin-mediated regulation of CD86 protein expression by the ubiquitin ligase membrane-associated RING-CH-1 (MARCH1).
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| Corcoran K, Jabbour M, Bhagwandin C, Deymier MJ, Theisen DL, Lybarger L.
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| J Biol Chem 286(43):37168-80. doi: 10.1074/jbc.M110.204040. Epub 2011 Sep 6. 2011
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| 13 | CD80, CD86, SPI1
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| Critical role of transcription factor PU.1 in the expression of CD80 and CD86 on dendritic cells.
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| Kanada S, Nishiyama C, Nakano N, Suzuki R, Maeda K, Hara M, Kitamura N, Ogawa H, Okumura K.
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| Blood 117(7):2211-22. doi: 10.1182/blood-2010-06-291898. Epub 2010 Nov 30.
2011
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| 14 | CD80, CD86
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| B7-1/2 (CD80/CD86) direct signaling to B cells enhances IgG secretion.
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| Rau FC, Dieter J, Luo Z, Priest SO, Baumgarth N.
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| J Immunol 183(12):7661-71. doi: 10.4049/jimmunol.0803783.
2009
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| 15 | CD86
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| Expression of CD86 on human islet endothelial cells facilitates T cell adhesion and migration.
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| Lozanoska-Ochser B, Klein NJ, Huang GC, Alvarez RA, Peakman M.
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| J Immunol 181(9):6109-16.
2008
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| 16 | CD86
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| Expression of the costimulatory molecule CD86, but not CD80, in keratinocytes of normal cervical epithelium and human papillomavirus-16 positive low squamous intraepithelial lesions.
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| Ortiz-Sanchez E, Chavez-Olmos P, Pina-Sanchez P, Salcedo M, Garrido E.
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| Int J Gynecol Cancer 17(3):571-80. Epub 2007 Mar 26. 2007
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| 17 | CD86
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| A functional CD86 polymorphism associated with asthma and related allergic disorders.
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| Corydon TJ, Haagerup A, Jensen TG, Binderup HG, Petersen MS, Kaltoft K, Vestbo J, Kruse TA, Borglum AD.
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| J Med Genet 44(8):509-15. Epub 2007 May 18. 2007
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| 18 | CD28, CD86
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| Ligation of CD28 by its natural ligand CD86 in the absence of TCR stimulation induces lipid raft polarization in human CD4 T cells.
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| Kovacs B, Parry RV, Ma Z, Fan E, Shivers DK, Freiberg BA, Thomas AK, Rutherford R, Rumbley CA, Riley JL, Finkel TH.
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| J Immunol 175(12):7848-54. 2005
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| 19 | CD86, CD80
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| CD86 and CD80 differentially modulate the suppressive function of human regulatory T cells.
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| Zheng Y, Manzotti CN, Liu M, Burke F, Mead KI, Sansom DM.
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| J Immunol 172(5):2778-84. 2004
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| 20 | CD86, CTLA4
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| Structural basis for co-stimulation by the human CTLA-4/B7-2 complex.
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| Schwartz JC, Zhang X, Fedorov AA, Nathenson SG, Almo SC.
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| Nature 410(6828):604-608. 2001
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| 21 | CD86
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| Identification of an alternatively spliced variant of human CD86 mRNA.
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| Magistrelli G, Caron G, Gauchat JF, Jeannin P, Bonnefoy JY, Delneste Y.
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| Biochem Biophys Res Commun 280(5):1211-5. 2001
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| 22 | CD86
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| Soluble CD86 is a costimulatory molecule for human T lymphocytes.
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| Jeannin P, Magistrelli G, Aubry JP, Caron G, Gauchat JF, Renno T, Herbault N, Goetsch L, Blaecke A, Dietrich PY, Bonnefoy JY, Delneste Y.
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| Immunity 13(3):303-12. 2000
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| 23 | CD86
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| Cloning and functional characterization of the 5'-regulatory region of the human CD86 gene.
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| Li J, Colovai AI, Cortesini R, Suciu-Foca N.
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| Hum Immunol 61(5):486-98. 2000
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| 24 | CD80, CD86
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| The costimulatory genes Cd80 and Cd86 are linked on mouse chromosome 16 and human chromosome 3.
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| Reeves RH, Patch D, Sharpe AH, Borriello F, Freeman GJ, Edelhoff S, Disteche C.
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| Mamm Genome 8(8):581-2. 1997
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| 25 | CD80, CD86
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| CD28/CTLA-4 ligands : the gene encoding CD86 (B70/B7.2) maps to the same region as CD80 (B7/B7.1) gene in human chromosome 3q13-q23.
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| Fernandez-Ruiz E, et al.
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| Eur J Immunol 25 : 1453-1456. 1995
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| 26 | CD86
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| Genomic organization of the gene coding for the costimulatory human B-lymphocyte antigen B7-2 (CD86).
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| Jellis CL, Wang SS, Rennert P, Borriello F, Sharpe AH, Green NR, Gray GS.
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| Immunogenetics 42(2):85-9. 1995
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| 27 | CD80, CD86, CTLA4
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| CTLA-4 is a second receptor for the B cell activation antigen B7.
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| Linsley PS, et al.
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| J Exp Med 174(3):561-9. 1991
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