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FLASH GENE

Symbol

NME1

contributors: mct/npt/pgu - updated : 20-12-2023

HGNC name	non-metastatic cells 1, protein (NM23A) expressed in
HGNC id	7849

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral somatic mutation       mutated in agressive neuroblastoma with a reduced expression in tumor progression to the metastatic phenotype tumoral     --over   correlated with poor neuroblastoma patient outcomes tumoral     --low   associated with aggressive forms of multiple cancers tumoral     --other   its expression is associated with poor prognosis in peripheral T-cell lymphoma

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	NME1 may serve as a biomarker useful in the prediction of fetal circulatory centralization and extremely low birth weight in pregnancies complicated by the early-onset FGR (Fetal Growth Restrictio
Therapy target

ANIMAL & CELL MODELS

NME1-deficient mouse embryo fibroblasts grew poorly in culture, were more sensitive to stress than WT fibroblasts, and did not immortalize, which suggested that they senesce earlier than do WT fibroblasts