| basic FUNCTION
| pyrimidine biosynthetic pathway, involved in the phosphorylation of nucleoside diphosphates |
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selectively regulates the PRKAA1, independently of the AMP concentration such that the manipulation of NME1 nucleotide trans-phosphorylation activity to generate ATP enhanced the activity of PRKAA1  |
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involved in the regulation of many cellular processes as well as in tumor metastasis |
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involved in epidermal homeostasis which depends on a tight regulation of the levels of NME1 isoforms |
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can negatively regulate cell migration and tumor metastasis by modulating the activity of CDC42 and possibly other Rho family members through interaction with MCF2 |
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having a 3prime-5prime exonuclease activity necessary for metastasis suppressor function |
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tumor metastasis suppressor, which functions as a nucleoside-diphosphate kinase converting nucleoside diphosphates to nucleoside triphosphates with an expense of ATP |
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may have a role in the regulation of cell cycle and apoptosis in human B-cells |
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loss of NME1, an event suspected to promote metastasis, may additionally function at an earlier stage of tumor development to drive the acquisition of chromosomal instability |
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critical for control of cell-cell adhesion and cell migration at early stages of the invasive program in epithelial cancers, orchestrating a barrier against conversion of in situ carcinoma into invasive malignancy |
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critical role for NME1 isoforms in limiting mutagenesis and suppressing UV radiation -induced melanomagenesis |
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exists in a functional cellular complex with PRKAA1 and CFTR in airway epithelia, and its catalytic function is required for the PRKAA1-dependent regulation of CFTR |
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may exert its anti-metastatic effect by blocking Ras/ERK signaling |
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NME1, NME2 have likely differential abilities to modulate tumorigenesis |
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NME1, NME5, NME7, and NME8 also exhibit a 3'-5' exonuclease activity, suggesting roles in DNA proofreading and repair |
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NME1 and, more recently, NME3, have been implicated in repair of both single- and double-stranded breaks in DNA |
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NME1 and NME2 have been identified as potential canonical transcription factors that regulate gene transcription through their DNA-binding activities |
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NME1, NME2 catalyze the transfer of gamma-phosphate from nucleoside triphosphates to nucleoside diphosphates by a ping-pong mechanism involving the formation of a high-energy phosphohistidine intermediate |
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NME1 induces transcription through its direct binding to the promoter region of a target gene |
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NME1 is required for non-homologous end joining (NHEJ) of DNA double-strand breaks (DSBs) |
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addition of NME1 or NME2 to DNM2 facilitates DNM2 oligomerization and increases GTPase activity, both required for vesicle scission |
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inhibition of cell migration and proliferation, alongside actions in apoptosis and phagocytosis are all mechanisms through which NME1 acts against metastatic progression |
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potential functional role for NME1 in neuroblastoma pathogenesis |
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NME1 is a powerful inhibitor of Epithelial-mesenchymal transition (EMT) |
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NME1, but not NME2, acts specifically to inhibit EMT and prevent the earliest stages of metastasis |
