| Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
|---|
| tumoral
|
| amplification
|
|
|
|
in childhood acute myeloid leukemia |
| tumoral
| somatic mutation
|
|
|
|
|
duplication mutations within the juxtamembrane domain in adult de novo acute myeloid leukemia |
| tumoral
| somatic mutation
|
|
|
|
|
in high hyperdiploid childhood acute lymphoblastic leukemia |
| tumoral
| somatic mutation
|
|
|
|
|
an internal tandem duplication (FLT3/ITD) is associated with poor prognosis in acute myeloid leukemia (AML), interaction with NPM1 mutations identify 3 prognostic groups: good (FLT3/ITD(-)NPM1(+)), intermediate (FLT3/ITD(-)NPM1(-) or FLT3/ITD(+)NPM1(+)), and poor (FLT3/ITD(+)NPM1(-)) |
| constitutional
|
|
|
| gain of function
|
activating mutations in FLT3 induce ligand-independent downstream signaling that promotes oncogenesis through pathways involved in proliferation, differentiation, and survival  |
|
| fusion
| translocation
|
|
|
|
ETV6/FLT3 (EF) fusion proteins in a patient with myeloproliferative disorder (MPD) and a t(12;13)(p13;q12) translocation |
