| 1 | DOCK2, FLT3
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| DOCK2 interacts with FLT3 and modulates the survival of FLT3-expressing leukemia cells.
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| Wu M, Hamaker M, Li L, Small D, Duffield AS.
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| Leukemia 31(3):688-696. doi: 10.1038/leu.2016.284. Epub 2016 Oct 17.
2017
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| 2 | FLT3, FYN
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| FYN expression potentiates FLT3-ITD induced STAT5 signaling in acute myeloid leukemia.
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| Chougule RA, Kazi JU, Rönnstrand L.
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| Oncotarget ncotarget. 2016 Feb 2. doi: 10.18632/oncotarget.7128. [Epub ahead of print]
2016
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| 3 | FLT3
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| NADPH oxidase-generated hydrogen peroxide induces DNA damage in mutant FLT3-expressing leukemia cells.
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| Stanicka J, Russell EG, Woolley JF, Cotter TG.
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| J Biol Chem 290(15):9348-61. doi: 10.1074/jbc.M113.510495. Epub 2015 Feb 19.
2015
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| 4 | FLT3
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| Correlation between FLT3-ITD status and clinical, cellular and molecular profiles in promyelocytic acute leukemias.
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| Souza Melo CP, Campos CB, Dutra ÁP, Neto JC, Fenelon AJ, Neto AH, Carbone EK, Pianovski MA, Ferreira AC, Assumpcão JG.
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| Leuk Res 39(2):131-7. doi: 10.1016/j.leukres.2014.11.010. Epub 2014 Nov 27.
2015
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| 5 | FLT3, HES1
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| Hes1 suppresses acute myeloid leukemia development through FLT3 repression.
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| Kato T, Sakata-Yanagimoto M, Nishikii H, Ueno M, Miyake Y, Yokoyama Y, Asabe Y, Kamada Y, Muto H, Obara N, Suzukawa K, Hasegawa Y, Kitabayashi I, Uchida K, Hirao A, Yagita H, Kageyama R, Chiba S.
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| Leukemia 29(3):576-85. doi: 10.1038/leu.2014.281. Epub 2014 Sep 19.
2015
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| 6 | FLT3, MUC1
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| MUC1-C oncoprotein promotes FLT3 receptor activation in acute myeloid leukemia cells.
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| Liu S, Yin L, Stroopinsky D, Rajabi H, Puissant A, Stegmaier K, Avigan D, Kharbanda S, Kufe D, Stone R.
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| Blood 123(5):734-42. doi: 10.1182/blood-2013-04-493858. Epub 2013 Nov 26.
2014
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| 7 | FLT3
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| Internal tandem duplication mutations in FLT3 gene augment chemotaxis to Cxcl12 protein by blocking the down-regulation of the Rho-associated kinase via the Cxcl12/Cxcr4 signaling axis.
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| Onish C, Mori-Kimachi S, Hirade T, Abe M, Taketani T, Suzumiya J, Sugimoto T, Yamaguchi S, Kapur R, Fukuda S.
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| J Biol Chem 289(45):31053-65. doi: 10.1074/jbc.M114.568287. Epub 2014 Sep 18. Erratum in: J Biol Chem. 2015 Nov 20;290(47):28356.
2014
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| 8 | CBFB, FLT3, RUNX1
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| Runx1 and Cbfβ regulate the development of Flt3+ dendritic cell progenitors and restrict myeloproliferative disorder.
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| Satpathy AT, Briseño CG, Cai X, Michael DG, Chou C, Hsiung S, Bhattacharya D, Speck NA, Egawa T.
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| Blood 123(19):2968-77. doi: 10.1182/blood-2013-11-539643. Epub 2014 Mar 27.
2014
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| 9 | FLT3
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| Functions of flt3 in zebrafish hematopoiesis and its relevance to human acute myeloid leukemia.
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| He BL, Shi X, Man CH, Ma AC, Ekker SC, Chow HC, So CW, Choi WW, Zhang W, Zhang Y, Leung AY.
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| Blood 123(16):2518-29. doi: 10.1182/blood-2013-02-486688. Epub 2014 Mar 3.
2014
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| 10 | FLT3
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| Flt3 signaling regulates the proliferation, survival, and maintenance of multipotent hematopoietic progenitors that generate B cell precursors.
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| Dolence JJ, Gwin KA, Shapiro MB, Medina KL.
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| Exp Hematol 42(5):380-393.e3. doi: 10.1016/j.exphem.2014.01.001. Epub 2014 Jan 18.
2014
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| 11 | FLT3
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| FLT3 tyrosine kinase inhibitors in acute myeloid leukemia: clinical implications and limitations.
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| Kayser S, Levis MJ.
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| Leuk Lymphoma 55(2):243-55. doi: 10.3109/10428194.2013.800198. Epub 2013 Jun 5. Review.
2014
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| 12 | BCL11A, FLT3, IL17RA
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| Bcl11a controls Flt3 expression in early hematopoietic progenitors and is required for pDC development in vivo.
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| Wu X, Satpathy AT, Kc W, Liu P, Murphy TL, Murphy KM.
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| PLoS One 8(5):e64800. doi: 10.1371/journal.pone.0064800. Print 2013.
2013
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| 13 | AFF1, FLT3, KMT2A
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| FLT3 activation cooperates with MLL-AF4 fusion protein to abrogate the hematopoietic specification of human ESCs.
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| Bueno C, Ayllón V, Montes R, Navarro-Montero O, Ramos-Mejia V, Real PJ, Romero-Moya D, Araúzo-Bravo MJ, Menendez P.
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| Blood 121(19):3867-78, S1-3. doi: 10.1182/blood-2012-11-470146. Epub 2013 Mar 11.
2013
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| 14 | FLT3, PTPRJ
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| Association of the protein-tyrosine phosphatase DEP-1 with its substrate FLT3 visualized by in situ proximity ligation assay.
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| Böhmer SA, Weibrecht I, Söderberg O, Böhmer FD.
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| PLoS One 8(5):e62871. doi: 10.1371/journal.pone.0062871. Print 2013.
2013
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| 15 | FLT3
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| Inhibition of FLT3 expression by green tea catechins in FLT3 mutated-AML cells.
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| Ly BT, Chi HT, Yamagishi M, Kano Y, Hara Y, Nakano K, Sato Y, Watanabe T.
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| PLoS One 8(6):e66378. doi: 10.1371/journal.pone.0066378. Print 2013.
2013
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| 16 | FLT3, HOXA9
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| Hoxa9 and Flt3 signaling synergistically regulate an early checkpoint in lymphopoiesis.
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| Gwin KA, Shapiro MB, Dolence JJ, Huang ZL, Medina KL.
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| J Immunol 191(2):745-54. doi: 10.4049/jimmunol.1203294. Epub 2013 Jun 14.
2013
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| 17 | FLT3, SOCS2
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| Suppressor of cytokine signaling 2 (SOCS2) associates with FLT3 and negatively regulates downstream signaling.
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| Kazi JU, Rönnstrand L.
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| Mol Oncol 7(3):693-703. doi: 10.1016/j.molonc.2013.02.020. Epub 2013 Mar 19.
2013
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| 18 | FLT3, SOCS6
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| Suppressor of cytokine signaling 6 (SOCS6) negatively regulates Flt3 signal transduction through direct binding to phosphorylated tyrosines 591 and 919 of Flt3.
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| Kazi JU, Sun J, Phung B, Zadjali F, Flores-Morales A, Rönnstrand L.
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| J Biol Chem 287(43):36509-17. doi: 10.1074/jbc.M112.376111. Epub 2012 Sep 5.
2012
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| 19 | FLT3
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| FLT3 expression initiates in fully multipotent mouse hematopoietic progenitor cells.
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| Buza-Vidas N, Woll P, Hultquist A, Duarte S, Lutteropp M, Bouriez-Jones T, Ferry H, Luc S, Jacobsen SE.
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| Blood 118(6):1544-8. doi: 10.1182/blood-2010-10-316232. Epub 2011 May 31.
2011
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| 20 | FLT3, MAPK14
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| FLT3-mediated p38-MAPK activation participates in the control of megakaryopoiesis in primary myelofibrosis.
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| Desterke C, Bilhou-Nabéra C, Guerton B, Martinaud C, Tonetti C, Clay D, Guglielmelli P, Vannucchi A, Bordessoule D, Hasselbalch H, Dupriez B, Benzoubir N, Bourgeade MF, Pierre-Louis O, Lazar V, Vainchenker W, Bennaceur-Griscelli A, Gisslinger H, Giraudier S, Le Bousse-Kerdilès MC; French Intergroup of Myeloproliferative Disorders,; French INSERM; European EUMNET Networks on Myelofibrosis.
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| Cancer Res 71(8):2901-15. doi: 10.1158/0008-5472.CAN-10-1731. Epub 2011 Apr 12. Erratum in: Cancer Res. 2011 Jun 1;71(11):4049-50.
2011
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| 21 | DLX1, DLX2, FLT3
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| Up-regulation of homeodomain genes, DLX1 and DLX2, by FLT3 signaling.
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| Starkova J, Gadgil S, Qiu YH, Zhang N, Hermanova I, Kornblau SM, Drabkin HA.
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| Haematologica 96(6):820-8. doi: 10.3324/haematol.2010.031179. Epub 2011 Feb 28.
2011
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| 22 | FLT3, PTPRj
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| Protein-tyrosine phosphatase DEP-1 controls receptor tyrosine kinase FLT3 signaling.
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| Arora D, Stopp S, Böhmer SA, Schons J, Godfrey R, Masson K, Razumovskaya E, Rönnstrand L, Tänzer S, Bauer R, Böhmer FD, Müller JP.
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| J Biol Chem 286(13):10918-29. doi: 10.1074/jbc.M110.205021. Epub 2011 Jan 24.
2011
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| 23 | FLT3
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| FLT3 as a therapeutic target in AML: still challenging after all these years.
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| Kindler T, Lipka DB, Fischer T.
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| Blood 116(24):5089-102. Epub 2010 Aug 12. Review.
2010
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| 24 | ETV6, FLT3, PIM1
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| The juxtamembrane domain in ETV6/FLT3 is critical for PIM-1 up-regulation and cell proliferation.
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| Vu HA, Xinh PT, Kano Y, Tokunaga K, Sato Y.
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| Biochem Biophys Res Commun 383(3):308-13. Epub 2009 Apr 5.
2009
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| 25 | FLT3, NRAS, KRAS, PTPN11
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| Mutations of FLT3, NRAS, KRAS, and PTPN11 are frequent and possibly mutually exclusive in high hyperdiploid childhood acute lymphoblastic leukemia.
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| Paulsson K, Horvat A, Stršmbeck B, Nilsson F, Heldrup J, Behrendtz M, Forestier E, Andersson A, Fioretos T, Johansson B.
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| Genes Chromosomes Cancer 47(1):26-33. 2008
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| 26 | FLT3, NPM1
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| The impact of FLT3 internal tandem duplication mutant level, number, size, and interaction with NPM1 mutations in a large cohort of young adult patients with acute myeloid leukemia.
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| Gale RE, Green C, Allen C, Mead AJ, Burnett AK, Hills RK, Linch DC; Medical Research Council Adult Leukaemia Working Party.
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| Blood 111(5):2776-84. Epub 2007 Oct 23.
2008
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| 27 | FLT3, NPM1
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| Clinical impact of nucleophosmin mutations and Flt3 internal tandem duplications in patients older than 60 yr with acute myeloid leukaemia.
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| Scholl S, Theuer C, Scheble V, Kunert C, Heller A, Mügge LO, Fricke HJ, Höffken K, Wedding U.
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| Eur J Haematol 80(3):208-15.
2008
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| 28 | FLT3
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| Abnormal localization and accumulation of FLT3-ITD, a mutant receptor tyrosine kinase involved in leukemogenesis.
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| Koch S, Jacobi A, Ryser M, Ehninger G, Thiede C.
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| Cells Tissues Organs 188(1-2):225-35. Epub 2008 Feb 27.
2008
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| 29 | FLT3
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| Human Flt3 is expressed at the hematopoietic stem cell and the granulocyte/macrophage progenitor stages to maintain cell survival.
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| Kikushige Y, Yoshimoto G, Miyamoto T, Iino T, Mori Y, Iwasaki H, Niiro H, Takenaka K, Nagafuji K, Harada M, Ishikawa F, Akashi K.
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| J Immunol 180(11):7358-67.
2008
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| 30 | FLT3
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| Importance of early detection and follow-up of FLT3 mutations in patients with acute myeloid leukemia.
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| Colovic N, Tosic N, Aveic S, Djuric M, Milic N, Bumbasirevic V, Colovic M, Pavlovic S.
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| Ann Hematol 86(10):741-7. Epub 2007 Jun 20.
2007
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| 31 | FLT3
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| Cloning and expression profile of FLT3 gene during progenitor cell-dependent liver regeneration.
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| Aydin IT, Tokcaer Z, Dalgic A, Konu O, Akcali KC.
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| J Gastroenterol Hepatol 22(12):2181-8.PMID: 18031378 2007
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| 32 | FLT3
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| FMS-like tyrosine kinase 3 in normal hematopoiesis and acute myeloid leukemia.
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| Parcells BW, Ikeda AK, Simms-Waldrip T, Moore TB, Sakamoto KM.
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| Stem Cells 24(5):1174-84. Epub 2006 Jan 12. Review.
2006
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| 33 | FLT3
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| Mutations of the FLT3 gene in adult acute myeloid leukemia: determination of incidence and identification of a novel mutation in a Thai population.
|
| Auewarakul CU, Sritana N, Limwongse C, Thongnoppakhun W, Yenchitsomanus PT.
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| Cancer Genet Cytogenet 162(2):127-34. 2005
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| 34 | KIT, FLT3
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| Incidence and prognosis of c-KIT and FLT3 mutations in core binding factor (CBF) acute myeloid leukaemias.
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| Care RS, Valk PJ, Goodeve AC, Abu-Duhier FM, Geertsma-Kleinekoort WM, Wilson GA, Gari MA, Peake IR, Lowenberg B, Reilly JT.
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| Br J Haematol 121(5):775-7. 2003
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| 35 | FLT3
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| Analysis of FLT3 length mutations in 1003 patients with acute myeloid leukemia: correlation to cytogenetics, FAB subtype, and prognosis in the AMLCG study and usefulness as a marker for the detection of minimal residual disease.
|
| Schnittger S, Schoch C, Dugas M, Kern W, Staib P, Wuchter C, Loffler H, Sauerland CM, Serve H, Buchner T, Haferlach T, Hiddemann W.
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| Blood 100(1):59-66. 2002
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| 36 | FLT3
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| PML/RARalpha and FLT3-ITD induce an APL-like disease in a mouse model.
|
| Kelly LM, Kutok JL, Williams IR, Boulton CL, Amaral SM, Curley DP, Ley TJ, Gilliland DG.
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| Proc Natl Acad Sci U S A 99(12):8283-8. 2002
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| 37 | FLT3
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| Mechanism of constitutive activation of FLT3 with internal tandem duplication in the juxtamembrane domain.
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| Kiyoi H, Ohno R, Ueda R, Saito H, Naoe T.
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| Oncogene 21(16):2555-63. 2002
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| 38 | FLT3
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| Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: association with FAB subtypes and identification of subgroups with poor prognosis.
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| Thiede C, Steudel C, Mohr B, Schaich M, Schakel U, Platzbecker U, Wermke M, Bornhauser M, Ritter M, Neubauer A, Ehninger G, Illmer T.
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| Blood 99(12):4326-35. 2002
|
| 39 | FLT3
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| Internal tandem duplication of the FLT3 gene and clinical evaluation in childhood acute myeloid leukemia. The Children's Cancer and Leukemia Study Group, Japan.
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| Iwai T, et al.
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| Leukemia 13(1):38-43. 1999
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| 40 | FLT3
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| Tandem duplication of the FLT3 gene is found in acute lymphoblastic leukaemia as well as acute myeloid leukaemia but not in myelodysplastic syndrome or juvenile chronic myelogenous leukaemia in children.
|
| Xu F, et al.
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| Br J Haematol 105(1):155-62. 1999
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| 41 | FLT3, FLT3LG
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| Biochemical and genetic characterization of multiple splice variants of the Flt3 ligand.
|
| McClanahan T, et al.
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| Blood 88 : 3371-3382. 1996
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| 42 | FLT3
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| Localization of the human stem cell tyrosine kinase-1 gene (FLT3) to 13q12-q13.
|
| Carow CE, et al.
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| Cytogenet Cell Genet 70 : 255-257. 1995
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| 43 | FLT1, FLT3
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| Characterization of a yeast artificial chromosome from human chromosome band 13q12 containing the FLT1 and FLT3 receptor-type tyrosine kinase genes.
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| Imbert A, Rosnet O, Marchetto S, Ollendorff V, Birnbaum D, Pebusque MJ.
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| Cytogenet Cell Genet 67(3):175-7. 1994
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| 44 | FLT3
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| STK-1, the human homolog of Flk-2/Flt-3, is selectively expressed in CD34+ human bone marrow cells and is involved in the proliferation of early progenitor/stem cells.
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| Small D, Levenstein M, Kim E, Carow C, Amin S, Rockwell P, Witte L, Burrow C, Ratajczak MZ, Gewirtz AM, et al.
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| Proc Natl Acad Sci U S A 91(2):459-63. 1994
|
| 45 | FLT1, FLT3
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| Close physical linkage of the FLT1 and FLT3 genes on chromosome 13 in man and chromosome 5 in mouse.
|
| Rosnet O, Stephenson D, Mattei MG, Marchetto S, Shibuya M, Chapman VM, Birnbaum D.
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| Oncogene 8(1):173-9. 1993
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| 46 | FLT3
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| Isolation and chromosomal localization of a novel FMS-like tyrosine kinase gene.
|
| Rosnet O, et al.
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| Genomics 9 : 380-385. 1991
|