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FLASH GENE
Symbol FBXO39 contributors: mct - updated : 04-01-2012
HGNC name F-box protein 39
HGNC id 28565
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an approximately 40-AA F-box motif
    • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • involved in substrate recognition and recruitment for ubiquitination
  • involved in the regulation of a wide variety of cellular processes (including the cell cycle, immune responses, signaling cascades and developmental events) through target proteins, such as cyclins, cyclin-dependent kinase inhibitors
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component SCF (Skp1-CUL-1-F-box protein) type E3 ubiquitin ligase complex
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerdigestivecolon
    may be useful for potential targets for colon cancer immunotherapy
    ANIMAL & CELL MODELS