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FLASH GENE
Symbol FBXO39 contributors: mct - updated : 04-01-2012
HGNC name F-box protein 39
HGNC id 28565
Location 17p13.1      Physical location : 6.679.551 - 6.690.964
Synonym symbol(s) Fbx39, MGC35179, BCP-20
DNA
TYPE functioning gene
STRUCTURE 11.41 kb     4 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 1673 - 442 - 2011 21338577
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrainhindbrainmedulla oblongata  
Reproductivefemale systemovary  moderately Homo sapiens
 female systemplacenta  moderately Homo sapiens
 male systemtestis  predominantly Homo sapiens
Respiratorylung   moderately Homo sapiens
cell lineage
cell lines
  • expressed broadly in various cancer cell lines including breast cancer cell lines, colon cancer cell lines, hepatoma cell lines, lung cancer cell lines, ovary cancer cell lines, renal cancer cell lines (1/2), sarcoma cell lines, and thyroid anaplastic cell lines
  • fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an approximately 40-AA F-box motif
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • involved in substrate recognition and recruitment for ubiquitination
  • involved in the regulation of a wide variety of cellular processes (including the cell cycle, immune responses, signaling cascades and developmental events) through target proteins, such as cyclins, cyclin-dependent kinase inhibitors
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component SCF (Skp1-CUL-1-F-box protein) type E3 ubiquitin ligase complex
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerdigestivecolon
    may be useful for potential targets for colon cancer immunotherapy
    ANIMAL & CELL MODELS