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FLASH GENE

Symbol

FBXO39

contributors: mct - updated : 04-01-2012

HGNC name	F-box protein 39
HGNC id	28565

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_153230 4 - 1673 - 442 - 2011 21338577

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain hindbrain medulla oblongata     Reproductive female system ovary     moderately Homo sapiens   female system placenta     moderately Homo sapiens   male system testis     predominantly Homo sapiens Respiratory lung       moderately Homo sapiens

cell lineage
cell lines	expressed broadly in various cancer cell lines including breast cancer cell lines, colon cancer cell lines, hepatoma cell lines, lung cancer cell lines, ovary cancer cell lines, renal cancer cell lines (1/2), sarcoma cell lines, and thyroid anaplastic cell lines
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

an approximately 40-AA F-box motif

HOMOLOGY

Homologene

FAMILY

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION

basic FUNCTION	involved in substrate recognition and recruitment for ubiquitination
	involved in the regulation of a wide variety of cellular processes (including the cell cycle, immune responses, signaling cascades and developmental events) through target proteins, such as cyclins, cyclin-dependent kinase inhibitors

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

SCF (Skp1-CUL-1-F-box protein) type E3 ubiquitin ligase complex

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer digestive colon may be useful for potential targets for colon cancer immunotherapy

ANIMAL & CELL MODELS