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FLASH GENE
Symbol SLC6A17 contributors: mct - updated : 21-03-2015
HGNC name solute carrier family 6, member 17
HGNC id 31399
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated GlycoP , PhosphoP
HOMOLOGY
Homologene
FAMILY
  • SLC6 family of structurally related, Na+-dependent transporter proteins
  • sodium:neurotransmitter symporter (SNF) family
    • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    text
  • predominant localization of heterologously expressed NTT4/XT1 to intracellular membranes )
  • synaptic vesicles
  • expression specifically in glutamatergic and some GABAergic neurons
    • basic FUNCTION
  • neutral amino acid transporter with a substrate profile similar to SLC6A15
  • orphan transporter, Na(+)-dependent, Cl(-)-independent
  • functions as a selective transporter of four amino acids (proline, glycine, leucine, and alanine), as well as glutamate
  • synaptic vesicular transporter of neutral amino acids and glutamate, playing an important role in the regulation of glutamatergic synapses
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other transport inhibited by low pH
    ASSOCIATED DISORDERS
    corresponding disease(s) MRT48
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS