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FLASH GENE
Symbol SLC6A17 contributors: mct - updated : 21-03-2015
HGNC name solute carrier family 6, member 17
HGNC id 31399
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
12 - 6422 80.9 727 - 2005 16125675
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain   predominantly Homo sapiens
 brainforebraincerebral cortex highly Homo sapiens
 brainlimbic systemhippocampus highly Homo sapiens
Reproductivefemale system    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervouscentral   
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousneuron Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated GlycoP , PhosphoP
HOMOLOGY
Homologene
FAMILY
  • SLC6 family of structurally related, Na+-dependent transporter proteins
  • sodium:neurotransmitter symporter (SNF) family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    text
  • predominant localization of heterologously expressed NTT4/XT1 to intracellular membranes )
  • synaptic vesicles
  • expression specifically in glutamatergic and some GABAergic neurons
  • basic FUNCTION
  • neutral amino acid transporter with a substrate profile similar to SLC6A15
  • orphan transporter, Na(+)-dependent, Cl(-)-independent
  • functions as a selective transporter of four amino acids (proline, glycine, leucine, and alanine), as well as glutamate
  • synaptic vesicular transporter of neutral amino acids and glutamate, playing an important role in the regulation of glutamatergic synapses
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other transport inhibited by low pH
    ASSOCIATED DISORDERS
    corresponding disease(s) MRT48
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS