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FLASH GENE

Symbol

CD276

contributors: mct - updated : 04-05-2016

HGNC name	CD276 antigen
HGNC id	19137

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Digestive liver         Endocrine pancreas         Reproductive female system breast mammary gland       female system uterus         male system testis         male system prostate

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective bone       Epithelial secretory glandular endocrine

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

embryo, neonatal, pregnancy

Text	expression increases during the last half of pregnancy, and is maximal during lactation, developing bone

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	an N-terminal signal peptide
	extracellular V- and C-like Ig domains with 4 conserved cysteine residues
	a transmembrane region
	a 45-amino acid cytoplasmic tail

conjugated

GlycoP

HOMOLOGY

interspecies

homolog to murine B7h3

Homologene

FAMILY	immunoglobulin superfamily, B7 immunoregulatory family
	BTN/MOG family

CATEGORY

immunity/defense , regulatory

SUBCELLULAR LOCALIZATION	extracellular
	plasma membrane

basic FUNCTION	may be acting as a specific membrane-associated receptor for the association of cytoplasmic droplets with the apical plasma membrane
	playing a regulatory role in bone formation
	negative regulator that preferentially affects T cell mediated immune responses
	function as a regulator of antitumor immunity
	HLA-G, CD274 and CD276, are secreted from early and term placenta, and have important implications in the mechanisms by which trophoblast immunomodulators modify the maternal immunological environment
	plays an important role in adaptive immune responses, and may have a novel role in regulating pancreatic tumor progression
	may have a critical role in primary hepatocellular carcinoma and it may enhance tumor escape from the immune surveillance of CD8(+) T cells
	might play an important role in angiogenesis of Renal cell carcinoma (RCC) mediated by CD14(+) monocytes

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in acute myeloid leukemia tumoral     --over   in oral squamous cell carcinoma (OSCC), and its overexpression correlated with larger tumor size, advanced clinical stage, and low survival rate in OSCC patients tumoral     --over   in the pancreatic cancer

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer hemopathy   CD276 silencing inhibits tumor progression of mantle cell lymphoma and enhances chemosensitivity cancer lung   is a promising target for new immunotherapeutic strategies in MM, with particular emphasis in the epithelial variant (malignant mesothelioma (MM)

ANIMAL & CELL MODELS